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Titolo:
Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling
Autore:
Lehmler, HJ; Robertson, LW;
Indirizzi:
Univ Kentucky, Grad Ctr Toxicol, Chandler Med Ctr, Lexington, KY 40536 USAUniv Kentucky Lexington KY USA 40536 ler Med Ctr, Lexington, KY 40536 USA
Titolo Testata:
CHEMOSPHERE
fascicolo: 8, volume: 45, anno: 2001,
pagine: 1119 - 1127
SICI:
0045-6535(200112)45:8<1119:SOHPMW>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID-HORMONE SULFATION; IN-VITRO INHIBITION; POLYCHLORINATED-BIPHENYLS; CHLORINATED BIPHENYLS; HUMAN SERUM; DERIVATIVES; MOUSE; RATS;
Keywords:
PCB; Suzuki-coupling; environmental contaminants;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Robertson, LW Univ Kentucky, Grad Ctr Toxicol, Chandler Med Ctr, 306 Hlth Sci Res Bldg, Lexington, KY 40536 USA Univ Kentucky 306 Hlth Sci Res Bldg Lexington KY USA 40536 A
Citazione:
H.J. Lehmler e L.W. Robertson, "Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling", CHEMOSPHERE, 45(8), 2001, pp. 1119-1127

Abstract

An improved synthesis of hydroxylated polychlorinated biphenyls (PCBs) which are structurally related to the major hydroxy PCB, congeners identified in human plasma is described. The coupling of (chlorinated) aryl boronic acids with bromochloro anisoles using the standard conditions of the Suzuki coupling gave the desired hydroxylated PCB metabolites in good to excellent yields. The approach offers the advantage of high selectivity and good yields compared to conventional methods such as the Cadogan reaction and allowsthe use of less toxic starting materials. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 17:05:58