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Titolo:
Volumetric and horseradish peroxidase tracing analysis of rat olfactory bulb following reversible olfactory nerve lesions
Autore:
Struble, RG; Beckman, SL; Fesser, E; Nathan, BP;
Indirizzi:
So Illinois Univ, Sch Med, Ctr Alzheimer Dis & Related Disorders, Springfield, IL 62794 USA So Illinois Univ Springfield IL USA 62794 ders, Springfield, IL 62794 USA Eastern Illinois Univ, Dept Biol Sci, Charleston, IL 61920 USA Eastern Illinois Univ Charleston IL USA 61920 i, Charleston, IL 61920 USA
Titolo Testata:
CHEMICAL SENSES
fascicolo: 8, volume: 26, anno: 2001,
pagine: 971 - 981
SICI:
0379-864X(200110)26:8<971:VAHPTA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
BROMIDE-INDUCED LESION; TYROSINE-HYDROXYLASE; DIETHYLDITHIOCARBAMATE DDTC; PERIPHERAL DEAFFERENTATION; MESSENGER-RNA; WGA-HRP; EPITHELIUM; SYSTEM; IMMUNOREACTIVITY; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Struble, RG So Illinois Univ, Sch Med, Ctr Alzheimer Dis & Related Disorders, POB 19628, Springfield, IL 62794 USA So Illinois Univ POB 19628 Springfield IL USA 62794 62794 USA
Citazione:
R.G. Struble et al., "Volumetric and horseradish peroxidase tracing analysis of rat olfactory bulb following reversible olfactory nerve lesions", CHEM SENSE, 26(8), 2001, pp. 971-981

Abstract

Olfactory receptor neurons can regenerate from basal stem cells. Receptor neuron lesion causes degenerative changes in the olfactory bulb followed byregeneration as new olfactory receptor axons innervate the olfactory bulb. To our knowledge, parametric analyses of morphometric changes in the olfactory bulb during degeneration and regeneration do not exist except in abstract form. To better characterize olfactcry bulb response, we performed morphometric analysis in rats following reversible olfactory nerve lesion with diethyldithiocarbamate. We also performed anterograde tracing of the olfactory nerve with wheatgerm agglutinin linked to horseradish peroxidase. Results of morphometry and tracing were complementary. The glomerular layer and external plexiform layer showed shrinkage of 45 and 26%, respectively, at 9days. No significant shrinkage occurred in any other layer. Individual glomeruli shrank by 40-50% at 3 and 9 days following lesion. These data show that degenerative changes occur both in the glomeruli and transneuronally inthe external plexiform layer. Olfactory nerve regeneration (identified by WGA-HRP transport) paralleled volumetric recovery. Recovery occurred first in ventral and lateral glomeruli between 9 and 16 days followed by recoveryin medial and dorsal glomeruli. These data indicate substantial transynaptic degeneration in the olfactory bulb and a heretofore unrecognized gradient in olfactory nerve regeneration that can be used to systematically study recovery of a cortical structure.

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Documento generato il 23/01/20 alle ore 12:39:50