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Titolo:
Molecular mechanism of hydrogen peroxide conversion and activation by Cu(II)-amikacin complexes
Autore:
Jezowska-Bojczuk, M; Lesniak, W; Bal, W; Kozlowski, H; Gatner, K; Jezierski, A; Sobczak, J; Mangani, S; Meyer-Klaucke, W;
Indirizzi:
Univ Wroclaw, Fac Chem, PL-50383 Wroclaw, Poland Univ Wroclaw Wroclaw Poland PL-50383 Fac Chem, PL-50383 Wroclaw, Poland Polish Acad Sci, Inst Biochem & Biophys, Warsaw, Poland Polish Acad Sci Warsaw Poland i, Inst Biochem & Biophys, Warsaw, Poland Univ Siena, Dept Chem, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 iv Siena, Dept Chem, I-53100 Siena, Italy EMBL Hamburg Outstn, D-22603 Hamburg, Germany EMBL Hamburg Outstn Hamburg Germany D-22603 tn, D-22603 Hamburg, Germany
Titolo Testata:
CHEMICAL RESEARCH IN TOXICOLOGY
fascicolo: 10, volume: 14, anno: 2001,
pagine: 1353 - 1362
SICI:
0893-228X(200110)14:10<1353:MMOHPC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
CATALASE-LIKE ACTIVITY; COPPER(II) COMPLEXES; COORDINATION ABILITY; BACTERICIDAL ACTION; OXYGEN ACTIVATION; AMINO-SUGARS; DIOXYGEN; BINDING; SITE; OTOTOXICITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Jezowska-Bojczuk, M Univ Wroclaw, Fac Chem, F Joliot Curie 14, PL-50383 Wroclaw, Poland Univ Wroclaw F Joliot Curie 14 Wroclaw Poland PL-50383
Citazione:
M. Jezowska-Bojczuk et al., "Molecular mechanism of hydrogen peroxide conversion and activation by Cu(II)-amikacin complexes", CHEM RES T, 14(10), 2001, pp. 1353-1362

Abstract

The interactions between Cu(II)-amikacin complexes [Cu(Il)-Amil and hydrogen peroxide were studied by spectroscopy (EPR, UV-vis, CD, XAS) and cyclic voltammetry. A monomer-dimer equilibrium was detected at complex concentrations above 5 mM (log K-dim = 1.84 +/- 0.03). The dimeric complex undergoes easy, although irreversible oxidation (ca. 0.5-0.6 V) to a Cu(III) species on platinum electrode. However, the monomeric complexes are able to catalyze hydrogen peroxide disproportionation reaction at pH 7.4 in a multistep process, mediated by hydroxyl radicals and involving both Cu(I)/Cu(II) and Cu(II)/Cu(III) redox pairs.

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Documento generato il 05/04/20 alle ore 09:37:47