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Titolo:
E2F repression by C/EBP alpha is required for adipogenesis and granulopoiesis in vivo
Autore:
Porse, BT; Pedersen, TA; Xu, XF; Lindberg, B; Wewer, UM; Friis-Hansen, L; Nerlov, C;
Indirizzi:
Univ Copenhagen Hosp, Lab Gene Therapy Res, DK-2100 Copenhagen O, Denmark Univ Copenhagen Hosp Copenhagen Denmark O DK-2100 Copenhagen O, Denmark Univ Copenhagen Hosp, Inst Pathol, DK-2100 Copenhagen, Denmark Univ Copenhagen Hosp Copenhagen Denmark DK-2100 2100 Copenhagen, Denmark Univ Copenhagen Hosp, Dept Clin Biochem, DK-2100 Copenhagen O, Denmark Univ Copenhagen Hosp Copenhagen Denmark O DK-2100 Copenhagen O, Denmark
Titolo Testata:
CELL
fascicolo: 2, volume: 107, anno: 2001,
pagine: 247 - 258
SICI:
0092-8674(20011019)107:2<247:ERBCAI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
BINDING-PROTEIN-ALPHA; CELL-PROLIFERATION; S-PHASE; RETINOBLASTOMA PROTEIN; LINEAGE COMMITMENT; ADIPOSE CONVERSION; PROGENITOR CELLS; GENE-EXPRESSION; NEWBORN MICE; DIFFERENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Nerlov, C Univ Copenhagen Hosp, Lab Gene Therapy Res, DK-2100 Copenhagen O, Denmark Univ Copenhagen Hosp Copenhagen Denmark O openhagen O, Denmark
Citazione:
B.T. Porse et al., "E2F repression by C/EBP alpha is required for adipogenesis and granulopoiesis in vivo", CELL, 107(2), 2001, pp. 247-258

Abstract

The C/EBP alpha transcription factor is required for differentiation of adipocytes and neutrophil granulocytes, and controls cellular proliferation in vivo. To address the molecular mechanisms of C/EBP alpha action, we have identified C/EBP alpha mutants defective in repression of E2F-dependent transcription and found them to be impaired in their ability to suppress cellular proliferation, and to induce adipocyte differentiation in vitro. Using targeted mutagenesis of the mouse germline, we show that E2F repression-deficient C/EBP alpha alleles failed to support adipocyte and granulocyte differentiation in vivo. These results indicate that E2F repression by C/EBP alpha is critical for its ability to induce terminal differentiation, and thus provide genetic evidence that direct cell cycle control by a mammalian lineageinstructive transcription factor couples cellular growth arrest and differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 05:49:12