Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Primary hepatic lymphoma - Favorable outcome after combination chemotherapy
Autore:
Page, RD; Romaguera, JE; Osborne, B; Medeiros, LJ; Rodriguez, J; North, L; Sanz-Rodriguez, C; Cabanillas, F;
Indirizzi:
Univ Texas, MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030USA Univ Texas Houston TX USA 77030 pt Lymphoma Myeloma, Houston, TX 77030USA Univ Texas, MD Anderson Canc Ctr, Dept Hematopathol, Houston, TX 77030 USAUniv Texas Houston TX USA 77030 Dept Hematopathol, Houston, TX 77030 USA Univ Texas, MD Anderson Canc Ctr, Dept Diagnost Imaging, Houston, TX 77030USA Univ Texas Houston TX USA 77030 pt Diagnost Imaging, Houston, TX 77030USA
Titolo Testata:
CANCER
fascicolo: 8, volume: 92, anno: 2001,
pagine: 2023 - 2029
SICI:
0008-543X(20011015)92:8<2023:PHL-FO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMA; B-CELL LYMPHOMA; INTERMEDIATE-GRADE; IMMUNOBLASTIC LYMPHOMA; PATHOLOGICAL FEATURES; MALIGNANT-LYMPHOMA; LIVER; PATIENT; CLASSIFICATION; INFECTION;
Keywords:
hepatic neoplasms; hepatitis C; lymphoma; treatment; primary hepatic non-Hodgkin lymphoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Romaguera, JE Univ Texas, MD Anderson Canc Ctr, Dept Lymphoma Myeloma, 1515 Holcombe Blvd, Houston, TX 77030 USA Univ Texas 1515 Holcombe Blvd Houston TX USA 77030 77030 USA
Citazione:
R.D. Page et al., "Primary hepatic lymphoma - Favorable outcome after combination chemotherapy", CANCER, 92(8), 2001, pp. 2023-2029

Abstract

Background. Primary hepatic non-Hodgkin lymphoma (PHL) is a rare and difficult to diagnose lymphoproliferative disorder of unknown etiology. It is believed that the prognosis in affected patients is dismal, consisting of early recurrence and 2 short survival. Methods. A retrospective cohort review of patients with PHL diagnosed between 1974 and 1995 at a university cancer center was performed. Results. Twenty-four patients with PHL were identified. Typically, the disease occurred in middle-aged men (median age, 50 years). The primary presenting complaint was right upper quadrant abdominal pain, with hepatomegaly found at physical examination. Serum liver enzymes, lactate dehydrogenase, and beta -2-microglobulin levels all were elevated, but a-fetoprotein and carcinoembryonic antigen levels were within normal range. Hypercalcemia was found in 6 of 15 patients who were tested. Six of 10 patients who were tested were positive for the hepatitis C virus (HCV). Liver scans demonstrated either a solitary lesion or multiple lesions. Pathologic examination revealed diffuse large cell lymphoma in 23 patients (96%). Combination chemotherapy was the mainstay of treatment; surgery consisted of diagnostic biopsy. The complete remission rate was 83.3%, and the 5-year cause specific and failure free survival rates were 87.1% and 70.1%, respectively. HCV infection did not appear to influence the outcome of therapy. Conclusions. The outcome of patients with PHL who are treated with combination chemotherapy may be more favorable than that reported elsewhere. The frequent association of PHL with HCV infection observed in this series warrants further investigation. Cancer 2001;92:2023-9. (C) 2001 American Cancer Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:36:48