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Titolo:
Opposing influences of glucocorticoids and interleukin-1 beta on the secretion of growth hormone and ACTH in the rat in vivo: role of hypothalamic annexin 1
Autore:
Philip, JG; John, CD; Cover, PO; Morris, JF; Christian, HC; Flower, RJ; Buckingham, JC;
Indirizzi:
Imperial Coll Sch Sci Technol & Med, Fac Med, Dept Neuroendocrinol, LondonW12 0NN, England Imperial Coll Sch Sci Technol & Med London England W12 0NN 0NN, England Univ Oxford, Dept Human Anat & Genet, Oxford OX1 3QX, England Univ OxfordOxford England OX1 3QX Anat & Genet, Oxford OX1 3QX, England St Bartholomews & Royal London Sch Med & Dent, William Harvey Res Inst, Dept Biochem Pharmacol, London EC1M 6BQ, England St Bartholomews & Royal London Sch Med & Dent London England EC1M 6BQ nd
Titolo Testata:
BRITISH JOURNAL OF PHARMACOLOGY
fascicolo: 4, volume: 134, anno: 2001,
pagine: 887 - 895
SICI:
0007-1188(200110)134:4<887:OIOGAI>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTERIOR-PITUITARY GLAND; INTRACEREBROVENTRICULAR PASSIVE-IMMUNIZATION; TUMOR-NECROSIS-FACTOR; IN-VITRO; ADRENOCORTICAL RESPONSES; LIPOCORTIN-1 REVERSES; INHIBITORY ACTIONS; SOMATOTROPIC AXIS; ADRENAL AXIS; N-TERMINUS;
Keywords:
annexin 1 (lipocortin 1); glucocorticoids; corticosterone; growth hormone; corticotrophin (ACTH);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Buckingham, JC Imperial Coll Sch Sci Technol & Med, Fac Med, Dept Neuroendocrinol, Commonwealth Bldg,Hammersmith Hosp Campus,Ducane, London W12 0NN, England Imperial Coll Sch Sci Technol & Med Commonwealth Bldg,Hammersmith Hosp Campus,Ducane London England W12 0NN
Citazione:
J.G. Philip et al., "Opposing influences of glucocorticoids and interleukin-1 beta on the secretion of growth hormone and ACTH in the rat in vivo: role of hypothalamic annexin 1", BR J PHARM, 134(4), 2001, pp. 887-895

Abstract

1 This study exploited established immunoneutralization protocols and an N-terminal annexin 1 peptide (annexin 1(Ac2-26)) to advance our knowledge ofthe role of annexin 1 as a mediator of acute glucocorticoid action in the rat neuroendocrine system in vivo.2 Rats were treated with corticosterone (500 mug kg(-1), i.p.) or annexin 1(Ac2-26) (0.1-10 ng rat(-1), i.c.v.) and 75 min later with interleukin 1 beta (IL-1 beta, 10 ng rat(-1), i.c.v. or 500 mug kg(-1), i.p). Blood was collected 1 h later for hormone immunoassay. Where appropriate, anti-annexin 1 polyclonal antiserum (pAb) was administered subcutaneously or centrally prior to the steroid challenge.3 Corticosterone did not affect the resting plasma corticotrophin (ACTH) concentration but suppressed the hypersecretion of ACTH induced by IL-1 beta(i.p. or i.c.v.). Its actions were quenched by anti-annexin 1 pAb (s.c. ori.c.v) and mimicked by annexin 1(Ac2-26).4 By contrast, corticosterone provoked an increase in serum growth hormone(GH) which was ablated by central but not peripheral administration of anti-annexin 1 pAb. IL-la (i.c.v. or i.p.) did not affect basal GH but, when given centrally but not peripherally, it abolished the corticosterone-induced hypersecretion of GH. Annexin 1(Ac2-26) (i.c.v.) also produced an increase in serum GH which was prevented by central injection of IL-1 beta.5 The results support the hypothesis that the acute regulatory actions of glucocorticoids on hypothalamo-pituitary-adrenocortical function require annexin 1. They also provide novel evidence that the positive influence of the steroids on GH secretion evident within this timeframe is effected centrally via an annexin 1-dependent mechanism which is antagonized by IL-1 beta.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:47:12