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Titolo:
Effect of neonatal treatment with monosodium glutamate on dopaminergic andL-DOPA-ergic neurons of the medial basal hypothalamus and on prolactin andMSH secretion of rats
Autore:
Bodnar, L; Gooz, P; Okamura, H; Toth, BE; Vecsernyes, M; Halasz, B; Nagy, GM;
Indirizzi:
Semmelweis Univ Med, Neuroendocrine Res Lab, Dept Human Morphol & Dev Biol, H-1094 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1094 ol, H-1094 Budapest, Hungary Kobe Univ, Sch Med, Dept Anat & Brain Sci, Kobe, Hyogo 650, Japan Kobe Univ Kobe Hyogo Japan 650 t Anat & Brain Sci, Kobe, Hyogo 650, Japan Med Sch Debrecen, Debrecen, Hungary Med Sch Debrecen Debrecen HungaryMed Sch Debrecen, Debrecen, Hungary
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 6, volume: 55, anno: 2001,
pagine: 767 - 774
SICI:
0361-9230(200108)55:6<767:EONTWM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
MELANOCYTE-STIMULATING HORMONE; AMINO-ACID DECARBOXYLASE; BLOOD-BRAIN-BARRIER; TYROSINE-HYDROXYLASE; ARCUATE NUCLEUS; PITUITARY-GLAND; INTERMEDIATE LOBE; MEDIOBASAL HYPOTHALAMUS; SEXUAL DIFFERENCES; ESTROUS-CYCLE;
Keywords:
arcuate nucleus; tyrosine hydroxylase; aromatic; L-amino acid decarboxylase; immunocytochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Nagy, GM Semmelweis Univ Med, Neuroendocrine Res Lab, Dept Human Morphol &Dev Biol, Tuzolto U 58, H-1094 Budapest, Hungary Semmelweis Univ Med Tuzolto U 58 Budapest Hungary H-1094 Hungary
Citazione:
L. Bodnar et al., "Effect of neonatal treatment with monosodium glutamate on dopaminergic andL-DOPA-ergic neurons of the medial basal hypothalamus and on prolactin andMSH secretion of rats", BRAIN RES B, 55(6), 2001, pp. 767-774

Abstract

The effect of neonatal treatment with monosodium L-glutamate (MSG) on the dopaminergic systems of the medial basal hypothalamus has been investigatedusing tyrosine hydroxylase (TH) and aromatic L-amino acid decarboxylase (AADC) immunocytochemistry. Changes in plasma levels of prolactin (PRL) and alpha -melanocyte-stimulating hormone (MSH) have also been determined in intact and in MSG-treated rats after inhibition of TH by alpha -methyl-p-tyrosine (alpha -MpT) or without inhibition of enzyme activity. Monosodium glutamate resulted in a 40% reduction in the number of TH immunopositive tuberoinfundibular neurons, but no change in the number of AADC-positive tuberoinfundibular nerve cells, indicating that this reduction has occurred mainly in TH-positive but AADC-negative elements, i.e., in L-DOPA-ergic neurons. Incontrast, MSG did not cause changes in the number of TH and AADC immunoreactive neurons of the periventriculohypophysial and tuberohypophysial dopaminergic systems, and it did not influence basal plasma PRL levels. alpha -methyl-p-tyrosine has increased plasma PRL concentrations in both control andMSG-treated rats of both sexes, but significantly higher responses were detected in females. None of the treatments had any effect on plasma MSH level. These findings suggest that MSG affects primarily L-DOPA-ergic neurons located in the ventrolateral part of the arcuate nucleus, but not dopaminergic neurons situated in the dorsomedial part of the arcuate nucleus; neitherPRL nor MSH secretion is altered by MSG; a significant sex difference exists in the pituitary PRL response to inhibition of TH, and this response is not affected by MSG. (C) 2001 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 16:07:08