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Titolo:
The anxiolytic effect of acute ethanol or diazepam exposure is unaltered in mu-opioid receptor knockout mice
Autore:
LaBuda, CJ; Fuchs, PN;
Indirizzi:
Univ Texas, Dept Psychol, Arlington, TX 76019 USA Univ Texas Arlington TXUSA 76019 , Dept Psychol, Arlington, TX 76019 USA
Titolo Testata:
BRAIN RESEARCH BULLETIN
fascicolo: 6, volume: 55, anno: 2001,
pagine: 755 - 760
SICI:
0361-9230(200108)55:6<755:TAEOAE>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ELEVATED PLUS-MAZE; ANXIETY; NALOXONE; RATS; ANTAGONISM; MORPHINE; CONSUMPTION; BEHAVIOR; AGONISTS; ALCOHOL;
Keywords:
ethanol; diazepam; opioid; mu-opioid receptor; knockout mouse; anxiety; elevated plus-maze;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: LaBuda, CJ Univ Texas, Dept Psychol, Box 19528, Arlington, TX 76019 USA Univ Texas Box 19528 Arlington TX USA 76019 ngton, TX 76019 USA
Citazione:
C.J. LaBuda e P.N. Fuchs, "The anxiolytic effect of acute ethanol or diazepam exposure is unaltered in mu-opioid receptor knockout mice", BRAIN RES B, 55(6), 2001, pp. 755-760

Abstract

Previous researchers demonstrate an opioidergic involvement in the anxiolytic and rewarding actions of ethanol and diazepam. Therefore, to further characterize the role of the opioid system in the anxiolytic action of ethanol and diazepam, normal (C57BL/6J), hybrid (B6129F1) and mu -opioid receptorknockout mice were given i.p. ethanol (0, 1.0 or 1.6 g/kg) or diazepam (1.5 mg/kg). The anxiolytic properties of these agents were then tested in theelevated plus-maze. Additional ethanol-treated mu -opioid receptor knockout mice (1 g/kg) were pretreated with the kappa -opioid receptor antagonist nor-BNI (0 or 3 mg/kg) to assess the involvement of kappa -opioid activity in ethanol's anxiolytic actions. The anxiolytic action of ethanol and diazepam in the mu -opioid receptor knockout mouse did not differ from the effects obtained in normal mice and pretreatment with nor-BNI did not significantly attenuate ethanol's actions in mu -opioid receptor knockout mice. Thus,the anxiolytic actions of ethanol and diazepam appear to be independent ofopioid system activity in the mu -opioid receptor knockout mouse. (C) 2001Elsevier Science.

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Documento generato il 02/04/20 alle ore 05:29:29