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Titolo:
Comparison of peripheral bone and body axis skeleton in a rat model of mild-to-moderate renal failure in the presence of physiological serum levels of calcitropic hormones
Autore:
Freesmeyer, MG; Abendroth, K; Faldum, A; Krauss, C; Stein, G;
Indirizzi:
Univ Jena, Dept Internal Med 4, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 ept Internal Med 4, D-07740 Jena, Germany Univ Mainz, Inst Med Stat & Documentat, D-6500 Mainz, Germany Univ Mainz Mainz Germany D-6500 Stat & Documentat, D-6500 Mainz, Germany
Titolo Testata:
BONE
fascicolo: 3, volume: 29, anno: 2001,
pagine: 258 - 264
SICI:
8756-3282(200109)29:3<258:COPBAB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR MESSENGER-RNA; PTH-PTHRP RECEPTOR; PARATHYROID-HORMONE; UREMIC RATS; CALCEMIC RESPONSE; ADYNAMIC BONE; SECONDARY HYPERPARATHYROIDISM; 1,25(OH)2D3 RECEPTORS; TREADMILL EXERCISE; MINERAL DENSITY;
Keywords:
secondary hyperparathyroidism; parathyroid hormone (PTH); PTH resistance; renal failure; uremia; calcitriol; bone histomorphometry; peripheral skeleton; tibia; axis skeleton; vertebra;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Freesmeyer, MG Univ Jena, Dept Internal Med 4, Erlanger Allee 101, D-07740Jena, Germany Univ Jena Erlanger Allee 101 Jena Germany D-07740 Germany
Citazione:
M.G. Freesmeyer et al., "Comparison of peripheral bone and body axis skeleton in a rat model of mild-to-moderate renal failure in the presence of physiological serum levels of calcitropic hormones", BONE, 29(3), 2001, pp. 258-264

Abstract

The skeleton is characterized by anatomic heterogeneity of metabolic turnover. Site-dependent differences in hormonal effects seem likely. Hyporesponsiveness of osteoclasts to parathyroid hormone (PTH) and probably calcitriol was recently demonstrated in the fifth lumbar vertebra of a rat model with moderate renal failure. We compared histomorphometric findings of the tibial head to these data. Histomorphometric measurements were carried out in sections of the right tibial head of pair-fed male Sprague-Dawley rats. Subtotally nephrectomized (SNx), parathyroidectomized (PTx), rats, which received either solvent or rat PTH(1-34) (100 ng/kg per hour) + calcitriol (5 pmoL/kg per hour) via osmotic minipumps were compared with sham-operated controls. Results were compared with data from the fifth lumbar vertebra reported recently. Osteoclast numerical density and osteoclast surface density were lower in the tibial head and the lumbar vertebra of solvent-treated SNxPTx rats than in sham-operated controls (p < 0.05), and could not be returned to normal by the substitution of PTH + calcitriol (p < 0.05). On the other hand, there were differences between interventional effects on the tibialhead and on the lumbar vertebra concerning parameters describing osteoblasts and trabecular bone volume. In the tibial head, osteoblast surface density was nearly unchanged in both interventions. Nevertheless, bone volume increased after SNxPTx without substitution of PTH + calcitriol (p < 0.05), and no further changes occurred after hormonal replacement. In contrast, osteoblast surface density in the lumbar vertebra was decreased slightly compared with values in sham-operated rats; a clear but nonsignificant increase occurred after the administration of calcitropic hormones. This was accompanied by unchanged trabecular bone volume after SNxPTx. Hormonal replacement, however, caused an increase in trabecular bone volume (p < 0.05), which represents an anabolic effect, which contrasts with findings from the tibialhead. The different interventional effects on the lumbar spine and on peripheral bone, regarding the parameters reflecting the condition of osteoblasts, may be intrinsic to the uremic syndrome itself as well as to dissimilargrowth manner, function, and mechanical requirements. The findings substantiate the site dependence of bone surface cell metabolism in renal failure and should be the subject of further study. Corresponding results with regard to bone resorption argue for a bone-site-independent, diminished response of osteoclasts to calcitropic hormones. (Bone 29:258-264; 2001) (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:08:10