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Titolo:
Interleukin-4 and interleukin-13: Bidirectional effects on human osteoclast formation
Autore:
Scopes, J; Massey, HM; Ebrahim, H; Horton, MA; Flanagan, AM;
Indirizzi:
Royal Free & Univ Coll Med Sch, Dept Histopathol, London, England Royal Free & Univ Coll Med Sch London England topathol, London, England Imperial Coll Sch Med, Dept Histopathol, London, England Imperial Coll SchMed London England Dept Histopathol, London, England Univ Coll London, Dept Med, Bone & Mineral Ctr, London, England Univ Coll London London England ed, Bone & Mineral Ctr, London, England
Titolo Testata:
BONE
fascicolo: 3, volume: 29, anno: 2001,
pagine: 203 - 208
SICI:
8756-3282(200109)29:3<203:IAIBEO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; INTERFERON-GAMMA; BONE-RESORPTION; GRANULOCYTE-MACROPHAGE; DIFFERENTIATION FACTOR; CELL-CULTURES; MAST-CELLS; IFN-GAMMA; TGF-BETA; M-CSF;
Keywords:
human; Th1/Th2; monocytes/macrophages; interleukin-4; interleukin-13; osteoclast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Flanagan, AM Univ London Univ Coll, Dept Histopathol, Rockefeller Bldg,Univ St, London WC1E 6JJ, England Univ London Univ Coll Rockefeller Bldg,Univ St London England WC1E 6JJ
Citazione:
J. Scopes et al., "Interleukin-4 and interleukin-13: Bidirectional effects on human osteoclast formation", BONE, 29(3), 2001, pp. 203-208

Abstract

Osteoclasts are cells that resorb bone; they derive from macrophage colony-stimulating factor (M-CSF)-dependent hematopoietic precursors in the presence of soluble activator of NF kappaB ligand (sRANKL). Because transforminggrowth factor (TGF)-beta, a macrophage deactivator, enhances osteoclast formation we hypothesized that interleukin (IL)-4 and IL-13, also macrophage deactivators, should exert a similar effect. However, IL-4 and IL-13 have been reported as suppressors of murine osteoclast formation. In contrast to the effect of these molecules on murine osteoclast formation, IL-4 and IL-13 were found to be powerful inducers of osteoclast formation and bone resorption when added to human peripheral blood mononuclear cell (PBMC) culturesfor 4 days. This stimulatory effect was only observed in cultures containing nonadherent PBMCs. In contrast, both molecules significantly suppressed osteoclast formation in lymphocyte-depleted cultures. These data demonstrate that the cytokine milieu and/or state of cell activation determines how cells of the osteoclast precursor respond to IL-4 and IL-13. (Bone 29: 203-208; 2001) (C) 2001 by Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 13:31:06