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Titolo:
Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT6 receptor
Autore:
Bromidge, SM; Griffith, K; Heightman, TD; Jennings, A; King, FD; Moss, SF; Newman, H; Riley, G; Routledge, C; Serafinowska, HT; Thomas, DR;
Indirizzi:
GlaxoSmithKline, Discovery Res, Discovery Chem Europe, Harlow CM19 5AW, Essex, England GlaxoSmithKline Harlow Essex England CM19 5AW ow CM19 5AW, Essex, England GlaxoSmithKline, Discovery Res, Dept Neurosci Res, Harlow CM19 5AW, Essex,England GlaxoSmithKline Harlow Essex England CM19 5AW low CM19 5AW, Essex,England
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 21, volume: 11, anno: 2001,
pagine: 2843 - 2846
SICI:
0960-894X(20011105)11:21<2843:N(AWHA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTAGONIST; SB-271046; POTENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Moss, SF GlaxoSmithKline, Discovery Res, Discovery Chem Europe, New Frontiers Sci Pk,3rd Ave, Harlow CM19 5AW, Essex, England GlaxoSmithKline New Frontiers Sci Pk,3rd Ave Harlow Essex England CM19 5AW
Citazione:
S.M. Bromidge et al., "Novel (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides with high affinity and selectivity for the 5-HT6 receptor", BIOORG MED, 11(21), 2001, pp. 2843-2846

Abstract

The discovery of (4-piperazin-1-ylquinolin-6-yl) arylsulfonamides and their binding affinites for a selection of 5-HT and dopamine subreceptors is described. Many compounds show high afffinity (pK(i) > 8) for the 5-HT6 receptor and > 100-fold selectivity against a range of other receptors. Structure-activity relationships of these compounds are discussed. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 00:09:51