Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Nutritional regulation of homocysteine: effects of drugs
Autore:
Varela-Moreiras, G;
Indirizzi:
Univ San Pablo CEU, Fac CC Expt & Salud, Madrid 28668, Spain Univ San Pablo CEU Madrid Spain 28668 Expt & Salud, Madrid 28668, Spain
Titolo Testata:
BIOMEDICINE & PHARMACOTHERAPY
fascicolo: 8, volume: 55, anno: 2001,
pagine: 448 - 453
SICI:
0753-3322(200110)55:8<448:NROHEO>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; THERMOLABILE METHYLENETETRAHYDROFOLATE REDUCTASE; PLASMA TOTAL HOMOCYSTEINE; MYOCARDIAL-INFARCTION; METHIONINE METABOLISM; S-ADENOSYLMETHIONINE; COFFEE CONSUMPTION; SERUM HOMOCYSTEINE; DIETARY-PROTEIN; FOLATE;
Keywords:
diet; drugs; homocysteine; vitamins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Varela-Moreiras, G Univ San Pablo CEU, Fac CC Expt & Salud, Urb Monteprincipe,Ctra Boadilla Km 5,3, Madrid 28668, Spain Univ San Pablo CEU Urb Monteprincipe,Ctra Boadilla Km 5,3 Madrid Spain 28668
Citazione:
G. Varela-Moreiras, "Nutritional regulation of homocysteine: effects of drugs", BIOMED PHAR, 55(8), 2001, pp. 448-453

Abstract

Homocysteine plays a critical regulation role at the intersection of two metabolic pathways: remethylation and transsulfuration. Both are nutritionally regulated per se, and this issue constitutes the main goal of the present short review. In addition, several factors (i.e., drugs) may change the nutritional modulation, altering the normal functioning of the methionine/methylation cycle. The metabolism of a substrate is closely linked to that ofit cofactors: in the case of homocysteine, there are three vitamins actingas cofactors or coenzymes: B6, B12 and folate. Vitamin B6 is involved in the formation of cystathionine from homocysteine (transsulfuration pathway). It is also critical for the formation of 5,10-methylentetrahydrofolate from tetrahydrofolate (folic acid derivatives), and therefore is closely related to the metabolism of folate. The latter is in conjunction with vitamin B12 involved in the remethylation of homocysteine to methionine. This reaction is B12-dependent. Different animal and human studies have proved the existence of a relation between vitamin status and homocysteine. Other dietarycomponents as methionine content, riboflavin, alcohol or coffee consumption are being investigated in relation to homocysteine concentration. Drugs may interfere with the utilization of nutrients. This fact may be of specialimportance for vitamins (i.e., folate). Administration of drugs in populations with adequate vitamin intake is not usually a problem, but the existence of risk groups (the elderly, adolescents, smokers, dieters, etc.) may lead to specific vitamin deficiencies which may lead to elevated homocysteine. The case of folate is analysed since this vitamin shows the most reportednumber of interactions with drugs. (C) 2001 Editions scientifiques et medicales Elsevier SAS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 18:26:36