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Titolo:
Recombinant relaxin - A review of pharmacology and potential therapeutic use
Autore:
Gavino, ES; Furst, DE;
Indirizzi:
Virginia Mason Res Ctr, Seattle, WA 98101 USA Virginia Mason Res Ctr Seattle WA USA 98101 es Ctr, Seattle, WA 98101 USA
Titolo Testata:
BIODRUGS
fascicolo: 9, volume: 15, anno: 2001,
pagine: 609 - 614
SICI:
1173-8804(2001)15:9<609:RR-ARO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-VIVO; FETAL MEMBRANES; COLLAGEN; GROWTH; CELLS; RATS; SCLERODERMA; FIBROBLASTS; EXPRESSION; SECRETION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Gavino, ES 1201 9th Ave,R1-RHE, Seattle, WA 98101 USA 1201 9th Ave,R1-RHESeattle WA USA 98101 Seattle, WA 98101 USA
Citazione:
E.S. Gavino e D.E. Furst, "Recombinant relaxin - A review of pharmacology and potential therapeutic use", BIODRUGS, 15(9), 2001, pp. 609-614

Abstract

Use of recombinant relaxin in the treatment of systemic sclerosis (or scleroderma) has been explored and determined as ineffective. However, continued research has revealed that relaxin is not limited to its role as a hormone. Relaxin has also been shown to decrease collagen formation and secretion, increase collagenase production, influence renal vasodilation, increase vascular endothelial growth factor expression and angiogenesis, promote dilation of blood vessels, and inhibit release of histamine. Further studies todiscover other potential uses of relaxin are well-justified.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/21 alle ore 16:11:53