Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Apolipoprotein A-II/A-I ratio is a key determinant in vivo of HDL concentration and formation of pre-beta HDL containing apolipoprotein A-II
Autore:
Pastier, D; Dugue, S; Boisfer, E; Atger, V; Tran, NQ; van Tol, A; Chapman, MJ; Chambaz, J; Laplaud, PM; Kalopissis, AD;
Indirizzi:
Univ Paris 06, INSERM, U505, Ctr Rech Cordeliers, F-75006 Paris, France Univ Paris 06 Paris France F-75006 ech Cordeliers, F-75006 Paris, France Hop La Pitie Salpetriere, INSERM, U551, F-75013 Paris, France Hop La PitieSalpetriere Paris France F-75013 551, F-75013 Paris, France Hop Broussais, Biochim Lab, F-75014 Paris, France Hop Broussais Paris France F-75014 s, Biochim Lab, F-75014 Paris, France Erasmus Univ, Dept Biochem, NL-3000 DR Rotterdam, Netherlands Erasmus Univ Rotterdam Netherlands NL-3000 DR DR Rotterdam, Netherlands
Titolo Testata:
BIOCHEMISTRY
fascicolo: 41, volume: 40, anno: 2001,
pagine: 12243 - 12253
SICI:
0006-2960(20011016)40:41<12243:AARIAK>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HIGH-DENSITY-LIPOPROTEIN; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; CORONARY HEART-DISEASE; C-TERMINAL HELIX; TRANSGENIC MICE; INCREASED PLASMA; ESTER TRANSFER; PARTICLE-SIZE; PROTEIN; ATHEROSCLEROSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Kalopissis, AD Univ Paris 06, INSERM, U505, Ctr Rech Cordeliers, 15 Rue Ecole Med, F-75006 Paris, France Univ Paris 06 15 Rue Ecole Med Paris FranceF-75006 France
Citazione:
D. Pastier et al., "Apolipoprotein A-II/A-I ratio is a key determinant in vivo of HDL concentration and formation of pre-beta HDL containing apolipoprotein A-II", BIOCHEM, 40(41), 2001, pp. 12243-12253

Abstract

Overexpression of human apolipoprotein A-II (apo A-H) in mice induced postprandial hypertriglyceridemia and marked reduction in plasma HDL concentration and particle size [Boisfer et al. (1999) J. Biol. Chem. 274, 11564-11572]. We presently compared lipoprotein metabolism in three transgenic lines displaying plasma concentrations of human apo A-If ranging from normal to 4times higher, under ad libitum feeding and after an overnight fast. Fasting dramatically decreased VLDL and lowered circulating human apo A-II in transgenic mice; conversely, plasma HDL levels increased in all genotypes. Theapo A-I content of HDL was inversely related to the expression of human apo A-II, probably reflecting displacement of apo A-I by an excess of apo A-H. Thus, the molar ratios of apo A-II/A-I in HDL were significantly higher in fed as compared with fasted animals of the same transgenic line, while endogenous LCAT activity concomitantly decreased. The number and size of HDL particles decreased in direct proportion to the level of human apo A-II expression. Apo A-II was abundantly present in all HDL particles, in contrast to apo A-I mainly present in large ones. Two novel findings were the presence of pre-beta migrating HDL transporting only human apo A-II in the higher-expressing mice and the increase of plasma HDL concentrations by fasting in control and transgenic mice. These findings highlight the reciprocal modifications of VLDL and HDL induced by the feeding-fasting transition and thekey role of the molar ratio of apo A-II/A-I as a determinant of HDL particle metabolism and pre-beta HDL formation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:37:56