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Titolo:
Human papillomavirus and cervical carcinogenesis
Autore:
Stanley, MA;
Indirizzi:
Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England Univ Cambridge Cambridge England CB2 1QP hol, Cambridge CB2 1QP, England
Titolo Testata:
BEST PRACTICE & RESEARCH IN CLINICAL OBSTETRICS & GYNAECOLOGY
fascicolo: 5, volume: 15, anno: 2001,
pagine: 663 - 676
SICI:
1521-6934(200110)15:5<663:HPACC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN EPITHELIAL-CELLS; HIGH-GRADE LESIONS; INTRAEPITHELIAL NEOPLASIA; E6 ONCOPROTEIN; FORESKIN KERATINOCYTES; TELOMERASE ACTIVITY; CIGARETTE-SMOKING; TRANSGENIC MICE; NATURAL-HISTORY; UTERINE CERVIX;
Keywords:
human papillomavirus; HPV; cervix; E6; E7 oncogenes; cell cycle controls; immortalization; genetic instability; aneuploidy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
86
Recensione:
Indirizzi per estratti:
Indirizzo: Stanley, MA Univ Cambridge, Dept Pathol, Tennis Court Rd, Cambridge CB2 1QP, England Univ Cambridge Tennis Court Rd Cambridge England CB2 1QP land
Citazione:
M.A. Stanley, "Human papillomavirus and cervical carcinogenesis", BEST P R CL, 15(5), 2001, pp. 663-676

Abstract

Epidemiological studies show that infection with a subset of genital humanpapillomavirus (HPV) infections is the major risk factor for the subsequent development of cervical cancer. Experimental studies show that that the E6 and E7 genes of these high risk HPVs are oncogenes that deregulate key cell cycle controls. In the normal infectious cycle high level expression of these genes is confined to non-dividing differentiated cells: HPV oncogenesis requires deregulation of viral and cellular genes permitting inappropriate expression of E6 and E7. These are rare events but viral persistence andchronic exposure to steroid hormones increase the probability of this deregulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:27:21