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Titolo:
Lymphoid neoplasms
Autore:
Oscier, DG; Gardiner, AC;
Indirizzi:
Royal Bournemouth Hosp, Dept Haematol, Bournemouth BH7 7DW, Dorset, England Royal Bournemouth Hosp Bournemouth Dorset England BH7 7DW Dorset, England
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 609 - 630
SICI:
1521-6926(200109)14:3<609:LN>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
B-CELL LYMPHOMA; IN-SITU-HYBRIDIZATION; CHRONIC LYMPHOCYTIC-LEUKEMIA; NON-HODGKINS-LYMPHOMA; T-PROLYMPHOCYTIC LEUKEMIA; MARGINAL ZONE LYMPHOMA; BCL-2 PROTEIN EXPRESSION; FOLLICLE CENTER LYMPHOMA; MULTIPLE-MYELOMA; MANTLE-CELL;
Keywords:
non-Hodgkin's lymphoma; chromosomes; FISH; PCR; prognosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
100
Recensione:
Indirizzi per estratti:
Indirizzo: Oscier, DG Royal Bournemouth Hosp, Dept Haematol, Castle Lane E, Bournemouth BH7 7DW,Dorset, England Royal Bournemouth Hosp Castle Lane E BournemouthDorset England BH7 7DW
Citazione:
D.G. Oscier e A.C. Gardiner, "Lymphoid neoplasms", BEST P R C, 14(3), 2001, pp. 609-630

Abstract

The majority of B cell lymphomas, but only a minority of T cell lymphomas,are characterized by recurring chromosome translocations. Many involve theimmunoglobulin or T cell receptor loci with various partner chromosomes and lead to abnormal proto-oncogene expression. Other recurring translocations result in the production of a novel fusion protein. The detection of translocations is of particular value in diagnosis and in the detection of minimal residual disease. Aneuploidy and deletion of specific chromosome regions are common secondary chromosomal events which are rarely specific to a particular type of lymphoma but provide valuable prognostic information. Analysis by G banding, 24-colour FISH and CGH provides global genomic information; however, more specifically directed investigations utilizing locus-specific FISH probes, PCR techniques or monoclonal antibodies may be more appropriate to answer particular questions regarding diagnosis and prognosis. The known molecular consequences of abnormalities and the appropriate methodsof detection are discussed for each subtype of lymphoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 13:21:44