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Titolo:
Acute lymphoblastic leukaemia
Autore:
Harrison, CJ;
Indirizzi:
Royal Free & Univ Coll, Sch Med, Leukaemia Res Fund,Karyotype Database Acute Lymph, UK Canc Cytogenet Grp,Dept Haematol, London NW3 2PF, England Royal Free & Univ Coll London England NW3 2PF l, London NW3 2PF, England
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 593 - 607
SICI:
1521-6926(200109)14:3<593:ALL>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEDIATRIC-ONCOLOGY-GROUP; POLYMERASE CHAIN-REACTION; CHILDRENS CANCER GROUP; IN-SITU HYBRIDIZATION; 11Q23 CHROMOSOMAL TRANSLOCATIONS; ACUTE MYELOID-LEUKEMIA; TEL/AML1 FUSION GENE; BCR-ABL ONCOGENE; CYTOGENETIC ABNORMALITIES; CLINICAL-SIGNIFICANCE;
Keywords:
cytogenetics; acute lymphoblastic leukaemia; genetic changes; genes; diagnosis; prognosis; fluorescence in situ hybridization (FISH);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
92
Recensione:
Indirizzi per estratti:
Indirizzo: Harrison, CJ Royal Free & Univ Coll, Sch Med, Leukaemia Res Fund,KaryotypeDatabase Acute Lymph, UK Canc Cytogenet Grp,Dept Haematol, Rowland Hill St, London NW3 2PF, England Royal Free & Univ Coll Rowland Hill St London England NW3 2PF
Citazione:
C.J. Harrison, "Acute lymphoblastic leukaemia", BEST P R C, 14(3), 2001, pp. 593-607

Abstract

In acute lymphoblastic leukaemia (ALL) the karyotype provides important prognostic information which is beginning to have an impact on treatment. Themost significant structural chromosomal changes include: the poor-risk abnormalities; t(9;22)(q34;q11), giving rise to the BCR/ABL fusion and rearrangements of the MLL gene; abnormalities previously designated as poor-risk; t(1;19)(q23;p13), producing the E2A/PBX1 and rearrangements of MYC with theimmunoglobulin genes; and the probable good risk translocation t(12;21)(p13;q22), which results in the ETV6/AML1 fusion. These abnormalities occur most frequently in B-lineage leukaemias, while rearrangements of the T cell receptor genes are associated with T-lineage ALL. Abnormalities of the shortarm of chromosome 9, in particular homozygous deletions involving the tumour suppressor gene (TSG) p16(INK4A), are associated with a poor outcome. Numerical chromosomal abnormalities are of particular importance in relation to prognosis. High hyperdiploidy (51-65 chromosomes) is associated with a good risk, whereas the outlook for patients with near haploidy (23-29 chromosomes) is extremely poor. In view of the introduction of risk-adjusted therapy into the UK childhood ALL treatment trials, an interphase FISH screening programme has been developed to reveal chromosomal abnormalities with prognostic significance in childhood ALL. Novel techniques in molecular cytogenetics are identifying new, cryptic abnormalities in small groups of patients which may lead to further improvements in future treatment protocols.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 09:55:15