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Titolo:
Childhood myeloid leukaemias
Autore:
Hall, GW;
Indirizzi:
John Radcliffe Hosp, Paediat Haematol Oncol Unit, Oxford OX3 9DU, England John Radcliffe Hosp Oxford England OX3 9DU Unit, Oxford OX3 9DU, England
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 573 - 591
SICI:
1521-6926(200109)14:3<573:CML>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
JUVENILE MYELOMONOCYTIC LEUKEMIA; TRANSIENT ABNORMAL MYELOPOIESIS; DIAMOND-BLACKFAN ANEMIA; CHRONIC MYELOGENOUS LEUKEMIA; DNA TOPOISOMERASE-II; BREAKPOINT CLUSTER REGION; COLONY-STIMULATING FACTOR; MYELODYSPLASTIC SYNDROME; INFANT LEUKEMIA; DOWN-SYNDROME;
Keywords:
AML; 11q23; infant leukaemia; childhood MDS; monosomy 7; JMML;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
111
Recensione:
Indirizzi per estratti:
Indirizzo: Hall, GW John Radcliffe Hosp, Paediat Haematol Oncol Unit, Headley Way, Oxford OX3 9DU, England John Radcliffe Hosp Headley Way Oxford England OX3 9DU , England
Citazione:
G.W. Hall, "Childhood myeloid leukaemias", BEST P R C, 14(3), 2001, pp. 573-591

Abstract

Childhood myeloid leukaemias are a diverse collection of conditions. Although many are also seen in adults, some are peculiar to childhood. In childhood AML, as in adults, cytogenetic abnormalities are associated with specific clinical features and define prognostic groups. In infants under 1 year with AML, the incidence of 11q23 abnormalities is particularly high. The finding of identical 11q23 breakpoints in infant leukaemia as in therapy-related leukaemias suggests a role for in utero exposure to topoisomerase II inhibitors. There are a number of constitutional disorders that predispose children to develop AML, usually with a preceding myelodysplastic phase. Monosomy (or deletion of the long arm) of chromosome 7 is the most frequent chromosome abnormality in the bone marrow of such patients. Abnormalities of chromosome 7 are also common cytogenetic findings in all morphological subgroups of childhood myelodysplasia, either as a primary abnormality or associated with disease progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:23:10