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Titolo:
The clinical significance of cytogenetic abnormalities in acute myeloid leukaemia
Autore:
Grimwade, D;
Indirizzi:
Guys Kings & St Thomas Sch Med, Div Med & Mol Genet, London, England Guys Kings & St Thomas Sch Med London England ol Genet, London, England Univ Coll London Hosp, Dept Haematol, London, England Univ Coll London Hosp London England sp, Dept Haematol, London, England
Titolo Testata:
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
fascicolo: 3, volume: 14, anno: 2001,
pagine: 497 - 529
SICI:
1521-6926(200109)14:3<497:TCSOCA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE PROMYELOCYTIC LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; ACUTE MYELOBLASTIC-LEUKEMIA; MINIMAL RESIDUAL DISEASE; ACUTE NONLYMPHOCYTIC LEUKEMIA; ACUTE MYELOMONOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; PML/RAR-ALPHA REARRANGEMENT; BONE-MARROW TRANSPLANTATION; TOPOISOMERASE-II INHIBITORS;
Keywords:
cytogenetics; AML; chromosomal translocations; acute promyelocytic leukaemia; cryptic and variant translocations; FISH; RT-PCR; minimal residual disease; clinical trials;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
172
Recensione:
Indirizzi per estratti:
Indirizzo: Grimwade, D Guys Hosp, Div Med & Mol Genet, Canc Genet Lab, Guys Kings & St Thomas SchMed, 8th Floor,Guys Tower, London SE1 9RT, England Guys Hosp 8th Floor,Guys Tower London England SE1 9RT England
Citazione:
D. Grimwade, "The clinical significance of cytogenetic abnormalities in acute myeloid leukaemia", BEST P R C, 14(3), 2001, pp. 497-529

Abstract

During the last three decades it has become apparent that the majority of cases of acute myeloid leukaemia (AML) are characterized by at least one ofa variety of recurrent chromosomal abnormalities. These changes have been found in many instances to correlate closely with distinct morphological features and clinical characteristics, the molecular basis of which is becoming increasingly understood. Furthermore, diagnostic karyotype has been shown to be a key determinant of outcome in AML, with mounting evidence to support the notion that cytogenetic analysis can serve to identify biologicallydistinct subsets of disease that demand tailored therapeutic approaches. This has led to a rising trend towards routine cytogenetic and molecular characterization of newly diagnosed acute leukaemia, providing a framework fortreatment stratification.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 23:28:15