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Titolo:
Dopamine receptors in the brains of schizophrenia patients: a meta-analysis of the findings
Autore:
Kestler, LP; Walker, E; Vega, EM;
Indirizzi:
Emory Univ, Dept Psychol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA30322 Univ, Dept Psychol, Atlanta, GA 30322 USA
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 5, volume: 12, anno: 2001,
pagine: 355 - 371
SICI:
0955-8810(200109)12:5<355:DRITBO>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; LIVING HUMAN-BRAIN; C-11 N-METHYLSPIPERONE; POST-MORTEM BRAINS; D-2 RECEPTORS; D2 RECEPTORS; COMPUTERIZED-TOMOGRAPHY; BINDING-SITES; BASAL GANGLIA; D4 RECEPTORS;
Keywords:
dopamine; schizophrenia; receptors; meta-analysis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Walker, E Emory Univ, Dept Psychol, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Psychol, Atlanta, GA 30322 USA
Citazione:
L.P. Kestler et al., "Dopamine receptors in the brains of schizophrenia patients: a meta-analysis of the findings", BEHAV PHARM, 12(5), 2001, pp. 355-371

Abstract

Controversy surrounds the question of whether there are dopamine (DA) receptor abnormalities in the brains of schizophrenia patients; in particular, whether DA receptors of the D-2 family are elevated in density. Methodological factors and sample characteristics have been postulated to account for differences in study outcome, but there has been no systematic analysis of the contribution of these factors to study effect sizes. This meta-analysisof the research findings sought to determine the influence of methodologicfactors and sample characteristics on the magnitude of diagnostic group differences in DA D-2 density (B-max) and affinity (K-d). The analysis suggests at least moderate effects, such that schizophrenia patients show an elevation in both values when compared to controls. These effects are amplifiedin medicated patients, but not solely attributable to antipsychotics. The group differences in DA D-2 receptor density and affinity increase with ageamong nonmedicated patients, The use of a butyrophenone ligand also yieldslarger effects. It is concluded that a subgroup of schizophrenia patients manifests increased DA D-2 receptor density and decreased receptor affinity. In the absence of medication, these changes may become more pronounced with age. Differences in study outcome are also partially due to methodologicfactors, including the ligand. (C) 2001 Lippincott Williams & Wilkins.

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Documento generato il 23/10/20 alle ore 13:47:27