Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Interaction of morphine and naltrexone on oral ethanol self-administrationin rhesus monkeys
Autore:
Williams, KL; Kane, EC; Woods, JH;
Indirizzi:
Univ Michigan, Dept Pharmacol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 t Pharmacol, Ann Arbor, MI 48109 USA
Titolo Testata:
BEHAVIOURAL PHARMACOLOGY
fascicolo: 5, volume: 12, anno: 2001,
pagine: 325 - 333
SICI:
0955-8810(200109)12:5<325:IOMANO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTAGONISTIC ACTIONS; OPIOID ANTAGONISTS; ALCOHOL DEPENDENCE; NALOXONE; DIFFERENTIATION; CONSUMPTION; DRINKING; QUADAZOCINE; PREFERENCE; RECEPTORS;
Keywords:
ethanol; opiate antagonists; opiate agonists; drinking; rhesus monkey;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, KL Univ Michigan, Dept Pharmacol, 1301 MSRB 3, Ann Arbor, MI 48109 USA Univ Michigan 1301 MSRB 3 Ann Arbor MI USA 48109 MI 48109 USA
Citazione:
K.L. Williams et al., "Interaction of morphine and naltrexone on oral ethanol self-administrationin rhesus monkeys", BEHAV PHARM, 12(5), 2001, pp. 325-333

Abstract

Opioid antagonists, such as naltrexone (NTX), reduce ethanol consumption and opioid agonists increase or decrease ethanol consumption in rats depending upon the dose. If the opioid antagonist and agonist effects on ethanol consumption are mediated by mu-opioid receptors, then NTX doses that reduce ethanol consumption should be similar to the doses necessary to antagonize the effects of opioid agonists on ethanol consumption. The purpose of theseexperiments was: (1) to determine whether morphine increases ethanol consumption in rhesus monkeys as it does in rodents; (2) to determine if the mu-receptor mediates the effects of morphine on ethanol consumption by conducting a pK(B) analysis using NTX; and (3) to determine if the mu-receptor also mediates the NTX-induced decreases in ethanol consumption by making comparisons between the NTX doses that affect ethanol consumption and the NTX doses that block the effects of morphine on ethanol consumption. Three male rhesus monkeys responded for 2% ethanol and water for 2 h/day on a fixed-ratio 4 schedule of reinforcement. Morphine doses as low as 0.0032 mg/kg failed to increase ethanol fluid deliveries, whereas higher doses produced a dose-related decrease in ethanol fluid deliveries. Although 0.01 mg/ kg NTX alone had no effect on ethanol fluid deliveries, it reduced the suppressant effects of morphine with a mu-receptor pK(B) of 8.21 (8.08-8.34). When givenalone, 0.1 mg/kg NTX decreased ethanol fluid deliveries but failed to reverse the suppression caused by 1 mg/kg morphine. Therefore, monkeys may differ from rats in their response to morphine when ethanol consumption is the dependent variable. Furthermore, because the NTX dose that reduced the effects of morphine on responding for ethanol was smaller than the NTX doses that suppressed ethanol-reinforced responding when given alone, NTX may exertthese two effects through different mechanisms. (C) 2001 Lippincott Williams and Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:52:55