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Titolo:
Hepato-vagal pathway associated with nicotine's anorectic effect in the rat
Autore:
Niijima, A; Miyata, G; Sato, T; Meguid, MM;
Indirizzi:
SUNY Hlth Sci Ctr, Upstate Med Univ, Dept Surg, Surg Metab & Nutrit Lab,Neurosci Program, Syracuse, NY 13210 USA SUNY Hlth Sci Ctr Syracuse NY USA 13210 i Program, Syracuse, NY 13210 USA Niigata Univ, Sch Med, Dept Physiol, Niigata 9518151, Japan Niigata Univ Niigata Japan 9518151 Dept Physiol, Niigata 9518151, Japan
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 93, anno: 2001,
pagine: 48 - 55
SICI:
1566-0702(20011008)93:1-2<48:HPAWNA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOOD-INTAKE; BODY-WEIGHT; SMOKING; LIVER; CESSATION; DOPAMINE; GLUCOSE;
Keywords:
nicotine; intra-portal vein injection; feeding pattern; electrophysiological method; curare; hexamethonium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Meguid, MM SUNY Hlth Sci Ctr, Upstate Med Univ, Dept Surg, Surg Metab & Nutrit Lab,Neurosci Program, 750 E Adams St, Syracuse, NY 13210 USA SUNY HlthSci Ctr 750 E Adams St Syracuse NY USA 13210 3210 USA
Citazione:
A. Niijima et al., "Hepato-vagal pathway associated with nicotine's anorectic effect in the rat", AUTON NEURO, 93(1-2), 2001, pp. 48-55

Abstract

Nicotine reduces appetite and body weight. Because the hepato-portal area senses different types of nutrients that transmit signals via vagal afferent nerves to the hypothalamus to modify food intake and feeding pattern, we investigated the effect of nicotine on a hepato-vagal-hypothalamic pathway. Low doses of nicotine (< 10 ng) injected into portal vein (ipv) decreased.while high doses of nicotine increased (greater than or equal to 10 ng) electrophysiological activity of hepatic vagal afferents. Stimulatory effect of high dose of nicotine on vagal hepatic afferents was blocked by a prior ipv injection of curare (30 mug) or hexamethonium (1 mg). Furthermore. activities of gastric vagal and adrenal sympathetic efferents were suppressed by low-dose, but stimulated by high-dose ipv nicotine, These reflex effects did not occur in hepatic vagotomized rats. Results of experiments demonstrate that in addition to nicotine's anorectic effect being mediated via a direct central action, nicotine also acts peripherally via hepatic vagal afferents from sensors of nicotine in the hepato-portal region. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/01/20 alle ore 09:30:13