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Titolo:
Glutaminergic vagal afferents may mediate both retching and gastric adaptive relaxation in dogs
Autore:
Furukawa, N; Hatano, M; Fukuda, H;
Indirizzi:
Kawasaki Med Univ, Dept Physiol, Kurashiki, Okayama 7010192, Japan Kawasaki Med Univ Kurashiki Okayama Japan 7010192 Okayama 7010192, Japan
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 93, anno: 2001,
pagine: 21 - 30
SICI:
1566-0702(20011008)93:1-2<21:GVAMMB>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLITARY NUCLEUS NEURONS; D-ASPARTATE RECEPTORS; NMDA RECEPTORS; GLUTAMATE-IMMUNOREACTIVITY; TRACTUS-SOLITARIUS; EMETIC ACT; TRANSMISSION; INPUTS; RAT; INTEGRATION;
Keywords:
retching; gastric relaxation; non-NMDA receptors; solitary tract nucleus; vagus nerve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Furukawa, N Kawasaki Med Univ, Dept Physiol, Kurashiki, Okayama 7010192, Japan Kawasaki Med Univ Kurashiki Okayama Japan 7010192 0192, Japan
Citazione:
N. Furukawa et al., "Glutaminergic vagal afferents may mediate both retching and gastric adaptive relaxation in dogs", AUTON NEURO, 93(1-2), 2001, pp. 21-30

Abstract

We previously reported that intra-4th-ventricular (i.4th.v.) administration of a non-NMDA receptor antagonist, NBQX, abolished vagally induced retching. This study was undertaken to ascertain whether or not the neuronal response in the solitary tract nucleus (NTS) to vagal stimulation and the vago-vagal gastric reflexes induced by non-emetic stimulation are also abolishedby NBQX with a similar latency as in the case of retching. Ketamine and thiopental- or chloralose-anesthetized dogs were decerebrated, and the dorsalsurface of the medulla was exposed. This study consisted of two series of experiments. In the first series, extracellular neuronal responses in the NTS to pulse-train vagal stimulation were recorded. Effects of NBQX on the neural response and vagally induced fictive retching were observed. In the second series, effects of glutamate receptor antagonists on gastric corpus responses to esophageal or gastric antral distension were observed. Retchingwas abolished 5-15 min after an i.4th.v. application of NBQX, and the neuronal responses disappeared within 14 min after application in nine of 10 NTS neurons. On the other hand, corpus contractility was inhibited by esophageal distension, and inhibited and/or enhanced by antral distension. While the inhibitory responses disappeared within 17 min after NBQX, the enhanced response remained even after NBQX and vagotomy, but was abolished by i.v. administration of hexamethonium. These results suggest that adaptive relaxation in the corpus, as well as retching, may be mediated by glutaminergic vagal afferents and non-NMDA receptors in the NTS. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 13:33:59