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Titolo:
Correlations between peripheral differential leukocyte counts and carotid atherosclerosis in non-smokers
Autore:
Huang, ZS; Jeng, HS; Wang, CH; Yip, PK; Wu, TH; Lee, TK;
Indirizzi:
Natl Taiwan Univ Hosp, Coll Med, Dept Internal Med, Taipei 10016, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan 10016 rnal Med, Taipei 10016, Taiwan Natl Taiwan Univ, Coll Med, Dept Neurol, Taipei 10018, Taiwan Natl Taiwan Univ Taipei Taiwan 10018 , Dept Neurol, Taipei 10018, Taiwan
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 2, volume: 158, anno: 2001,
pagine: 431 - 436
SICI:
0021-9150(200110)158:2<431:CBPDLC>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; SEX-DIFFERENCES; RISK-FACTORS; CELL COUNT; MONOCYTES; ELASTASE; ADHESION; SMOKING;
Keywords:
carotid atherosclerosis; leukocyte count; neutrophils; monocytes; gender; atherogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Huang, ZS Natl Taiwan Univ Hosp, Coll Med, Dept Internal Med, 7 Chung ShanS Rd, Taipei 10016, Taiwan Natl Taiwan Univ Hosp 7 Chung Shan S Rd TaipeiTaiwan 10016 wan
Citazione:
Z.S. Huang et al., "Correlations between peripheral differential leukocyte counts and carotid atherosclerosis in non-smokers", ATHEROSCLER, 158(2), 2001, pp. 431-436

Abstract

Substantial evidence clearly indicates the immuno-inflammatory nature of atherosclerosis and the important roles of monocytes and other leukocytes inatherogenesis. The relationship between atherosclerosis and the peripheralmonocyte count, however, has been equivocal and uncertain so far, One possible reason may be an opposing effect of different major risk factors of atherosclerosis on the monocyte count, e.g. smoking increases the monocyte count while hypercholesterolemia is accompanied by a lower monocyte count. Since smoking is well shown to increase leukocyte counts prominently in weeks, our study included only non-smokers who participated in a health check program at our hospital from 1996 to 1998 and had received a carotid duplex study with extra payment. Our results revealed the followings: In male non-smokers (n = 571), the presence of carotid atherosclerosis was associated with significant increases in the counts of all leukocyte, neutrophil, and monocyte (P < 0.005, < 0.001 and < 0.05, respectively), and, after adjustments for age and body mass index, there were significant positive links between these three leukocyte counts and the severity of carotid atherosclerosis,judged by either the sum score of all carotid plaques or the score of the most severe carotid plaque. On the contrary, in female non-smokers (n = 614), there was no significant link between differential leukocyte counts and either the presence or severity of carotid atherosclerosis. These results are compatible with recently recognized sex differences in the mechanism andpathophysiology of atherosclerosis, and together with relevant results in the literature, suggest that monocytes and neutrophils are the main types of leukocytes involved in atherosclerosis. (C) 2001 Elsevier Science IrelandLtd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 20:04:03