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Titolo:
NICOTINIC AND MUSCARINIC CHOLINERGIC RECEPTOR-BINDING IN THE HUMAN HIPPOCAMPAL-FORMATION DURING DEVELOPMENT AND AGING
Autore:
COURT JA; LLOYD S; JOHNSON M; GRIFFITHS M; BIRDSALL NJM; PIGGOTT MA; OAKLEY AE; INCE PG; PERRY EK; PERRY RH;
Indirizzi:
NEWCASTLE GEN HOSP,MRC,NEUROCHEM PATHOL UNIT,WESTGATE RD NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND NATL INST MED RES,DIV PHYS BIOCHEM LONDON NW7 1AA ENGLAND NEWCASTLE GEN HOSP,DEPT PATHOL NEWCASTLE TYNE NE4 6BE TYNE & WEAR ENGLAND
Titolo Testata:
Developmental brain research
fascicolo: 1-2, volume: 101, anno: 1997,
pagine: 93 - 105
SICI:
0165-3806(1997)101:1-2<93:NAMCRI>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT-BRAIN REGIONS; HUMAN-FETAL BRAIN; PROTEIN-KINASE-C; MEDIATED PHOSPHOINOSITIDE HYDROLYSIS; QUINUCLIDINYL BENZILATE BINDING; AGE-RELATED-CHANGES; ALZHEIMERS-DISEASE; CEREBRAL-CORTEX; ALPHA-BUNGAROTOXIN; FRONTAL-CORTEX;
Keywords:
NICOTINIC RECEPTOR; ALPHA-BUNGAROTOXIN RECEPTOR; MUSCARINIC RECEPTOR; HUMAN BRAIN; HIPPOCAMPUS; ENTORHINAL CORTEX; DEVELOPMENT; AGING;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
123
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Court et al., "NICOTINIC AND MUSCARINIC CHOLINERGIC RECEPTOR-BINDING IN THE HUMAN HIPPOCAMPAL-FORMATION DURING DEVELOPMENT AND AGING", Developmental brain research, 101(1-2), 1997, pp. 93-105

Abstract

High-affinity nicotine, alpha-bungarotoxin (alpha BT) and muscarinic receptor binding was measured in the human hippocampal formation in a series of 57 cases aged between 24 weeks gestation and 100 years. Changes in nicotine receptor binding during development and aging were more striking than differences in alpha BT and muscarinic binding. Nicotine binding was higher at the late foetal stage than at any other subsequent time in all areas investigated. In the hippocampus a fall in binding then occurred within the first six months of life, with little orno subsequent fall during aging, whereas in the entorhinal cortex andthe presubiculum the major loss of nicotine binding occurred after the fourth decade. alpha BT binding was significantly elevated in the CA1 region, but in no other region of the hippocampus, in the late foetus, and there was also a fall in alpha BT binding in the entorhinal cortex during aging from the second decade. The modest changes in total muscarinic binding, which appeared to reflect those in M1 and M3 + 4 rather than M2 binding, were a rise in the entorhinal cortex between the foetal stage and childhood and a tendency for receptors to fall withage in the hippocampus and subicular complex. These findings implicate mechanisms controlling the expression of nicotinic receptors to a greater extent than muscarinic receptors in postnatal development and aging in the human hippocampus. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 13:16:39