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Titolo:
Synthesis and antinociceptive activity of [(2-oxobenzothiazolin-3-yl)methyl]-4-alkyl/aryl-1,2,4-triazoline-5-thiones
Autore:
Gokce, M; Cakir, B; Erol, K; Sahin, MF;
Indirizzi:
Gazi Univ, Dept Pharmaceut Chem, Fac Pharm, TR-06330 Ankara, Turkey Gazi Univ Ankara Turkey TR-06330 hem, Fac Pharm, TR-06330 Ankara, Turkey Osman Gazi Univ, Dept Pharmacol, Fac Med, Eskisehir, Turkey Osman Gazi Univ Eskisehir Turkey Pharmacol, Fac Med, Eskisehir, Turkey
Titolo Testata:
ARCHIV DER PHARMAZIE
fascicolo: 8-9, volume: 334, anno: 2001,
pagine: 279 - 283
SICI:
0365-6233(200109)334:8-9<279:SAAAO[>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTICONVULSANT ACTIVITY; DERIVATIVES;
Keywords:
2-oxobenzothiazolines; thiosemicarbazide derivatives; 1,2,4-triazoline-5-thiones; antinociceptive activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Sahin, MF Gazi Univ, Dept Pharmaceut Chem, Fac Pharm, TR-06330 Ankara, Turkey Gazi Univ Ankara Turkey TR-06330 harm, TR-06330 Ankara, Turkey
Citazione:
M. Gokce et al., "Synthesis and antinociceptive activity of [(2-oxobenzothiazolin-3-yl)methyl]-4-alkyl/aryl-1,2,4-triazoline-5-thiones", ARCH PHARM, 334(8-9), 2001, pp. 279-283

Abstract

The synthesis and pharmacological evaluation of new [(2-oxobenzothiazolin-3-yl)-methyl]-4-alkyl/aryl-1,2,4-triazoline-5-thiones are reported. All compounds were screened for analgesic and antiinflammatory activities by usingthe AcOH induced-stretching test, the hot plate test, the tail clip test, and the tail flick test. All of the title compounds showed more potent activity than the standard compound aspirin in the AcOH induced-stretching test. In the hot plate test [(2-oxobenzothiazolin-3-yl)methyl]-4-phenethyl-1,2,4-triazoline-5-thione 5j were revealed to be two-fold more potent in antinociceptive activity than novalgine. However, in the tail flick and tail cliptest none of the compounds showed an antinociceptive activity as high as that of novalgine. On the basis of available data the structure-activity relationship in the [(2-oxobenzothiazolin-3-yl)methyl]-4-alkyl/aryl-1,2,4-triazoline-5-thiones was also discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 22:24:17