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Titolo:
Air pollutants enhance rhinoconjunctivitis symptoms in pollen-allergic individuals
Autore:
Riediker, M; Monn, C; Koller, T; Stahel, WA; Wuthrich, B;
Indirizzi:
Swiss Fed Inst Technol, Inst Hyg & Appl Physiol, Environm Hyg Sect, Zurich, Switzerland Swiss Fed Inst Technol Zurich Switzerland Hyg Sect, Zurich, Switzerland Swiss Fed Inst Technol, ETH Zurich, Seminar Stat, Zurich, Switzerland Swiss Fed Inst Technol Zurich Switzerland nar Stat, Zurich, Switzerland Univ Zurich Hosp, Dept Dermatol, Allergy Unit, CH-8091 Zurich, SwitzerlandUniv Zurich Hosp Zurich Switzerland CH-8091 CH-8091 Zurich, Switzerland
Titolo Testata:
ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY
fascicolo: 4, volume: 87, anno: 2001,
pagine: 311 - 318
SICI:
1081-1206(200110)87:4<311:APERSI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITROGEN-DIOXIDE; ASTHMATIC SUBJECTS; OZONE EXPOSURE; POLLUTION; INFLAMMATION; ASSOCIATION; INHALATION; PREVALENCE; RESPONSES; PARTICLES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Riediker, M Univ N Carolina, Ctr Environm Med & Lung Biol, EPA Human Studies Facil, CB7310,104 Mason Farm Rd, Chapel Hill, NC 27599 USA Univ N Carolina CB 7310,104 Mason Farm Rd Chapel Hill NC USA 27599
Citazione:
M. Riediker et al., "Air pollutants enhance rhinoconjunctivitis symptoms in pollen-allergic individuals", ANN ALLER A, 87(4), 2001, pp. 311-318

Abstract

Background: Little is know about the relation of airborne pollen allergensto nasal and ocular symptoms in combination with air pollutants. Objective: The hypothesis was that air pollutants exacerbate allergic symptoms of the nose and eyes during the pollen season. In addition, the use ofallergen measurements instead of pollen counts should be tested. Methods: Fifteen pollen-allergic, nonsmoking subjects with weak reactivityof the airways recorded rhinoconjunctival symptoms and medication every morning and evening throughout the pollen season. Symptoms were compared withair pollutants (nitrogen oxide [NOx], particulate matter smaller than 10 mum, and ozone) and birch and grass pollen counts or, alternatively, to airborne birch and grass allergens determined using ELISA-techniques. A multiple linear regression model was used which controlled for autocorrelation of the residuals of the time series (Cochrane-Orcutt approach). This model wasapplied to each subject individually, followed by calculations of summary scores for the group. Results: Air pollution levels were moderate, often meeting air quality standards. Effect estimates (increase of score with 10-fold increase of concentration) were NOx = 1.06, P < 0.01; ozone = 1.59, P < 0.01; and pollen = 0.48, P < 0.001. Using allergen concentrations instead of pollen counts resulted in similar effect estimates. Using particulate matter smaller than 10 <mu>m instead of NOx gave comparable but less consistent results. Conclusions: Symptoms were related to moderate levels of pollutants, suggesting that rhinoconjunctival tissue is very sensitive to irritant stimuli during an ongoing allergic inflammation, and that susceptibility toward allergens might be increased in areas with increased levels of air pollutants. Allergen measurements seem equally usable as pollen counts to investigate rhinoconjunctivitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 01:00:10