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Titolo:
Hormonal control of arylhydrocarbon receptor (AhR) expression in the preimplantation rabbit uterus
Autore:
Hasan, A; Fischer, B;
Indirizzi:
Univ Halle Wittenberg, Fac Med, Dept Anat & Cell Biol, D-06097 Halle Saale, Saale, Germany Univ Halle Wittenberg Halle Saale Saale Germany D-06097 e, Saale, Germany
Titolo Testata:
ANATOMY AND EMBRYOLOGY
fascicolo: 3, volume: 204, anno: 2001,
pagine: 189 - 196
SICI:
0340-2061(200109)204:3<189:HCOAR(>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARYL-HYDROCARBON RECEPTOR; POLYCHLORINATED-BIPHENYLS PCBS; IN-VITRO FERTILIZATION; HEAT-SHOCK PROTEIN; NUCLEAR TRANSLOCATOR; REPRODUCTIVE TOXICITY; DNA-BINDING; GENE; 2,3,7,8-TETRACHLORODIBENZO-PARA-DIOXIN; LIGAND;
Keywords:
arylhydrocarbon receptor (AhR); preimplantation period; endometrium; steroid hormones;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Hasan, A Univ Halle Wittenberg, Fac Med, Dept Anat & Cell Biol, Grosse Steinstr 52,D-06097 Halle Saale, Saale, Germany Univ Halle Wittenberg Grosse Steinstr 52 Halle Saale Saale Germany D-06097
Citazione:
A. Hasan e B. Fischer, "Hormonal control of arylhydrocarbon receptor (AhR) expression in the preimplantation rabbit uterus", ANAT EMBRYO, 204(3), 2001, pp. 189-196

Abstract

We show that the arylhydrocarbon receptor (AhR) is localised in a distinctpattern in the preimplantation rabbit uterus. Employing immunohistochemistry, uteri from mature and immature rabbits were studied in different pregnancy stages during the preimplantation period (non-pregnant/estrous, pregnant and pseudopregnant) and following treatment with estradiol and progesterone, respectively. The staining patterns in pregnant and pseudopregnant rabbits were similar, indicating a primary maternal control of expression. A distinct change in AhR localization occurred in the endometrium of (1) non-pregnant compared with pregnant rabbits and (2) shortly prior to the anticipated time of implantation. Compared with non-pregnant uteri, the AhR was no longer restricted to a small cytoplasmic area apical to the nucleus but wasfound in the entire cytoplasm and in the nuclei of the endometrial epithelial cells in pregnant uteri. Prior to implantation, at day 6, stromal cellsand the epithelium of the uterine glands, but no longer the luminal epithelial cells, were immunopositive. The estradiol-treated immature uteri showed a strong expression in the luminal epithelium and in some uterine glands,often with nuclear staining, while the estradiol-primed and progesterone-treated specimens had a similar staining pattern as mature preimplantation uteri. Present results demonstrate a distinct localization pattern of the AhR in the endometrium during the preimplantation period. Stage-specific changes in the expression pattern indicate control of AhR expression by maternal steroid hormones.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 01:18:42