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Titolo:
Role of CXC-chemokines in the pathogenesis of the acute respiratory distress syndrome
Autore:
Beck, G; von Zabern, D;
Indirizzi:
Univ Klinikum Mannheim, Inst Anasthesiol & Operat Intens Med, D-68167 Mannheim, Germany Univ Klinikum Mannheim Mannheim Germany D-68167 -68167 Mannheim, Germany
Titolo Testata:
ANASTHESIOLOGIE & INTENSIVMEDIZIN
, volume: 42, anno: 2001,
pagine: 671 - 679
SICI:
0170-5334(200109)42:<671:ROCITP>2.0.ZU;2-O
Fonte:
ISI
Lingua:
GER
Soggetto:
MICROVASCULAR ENDOTHELIAL-CELLS; BRONCHOALVEOLAR LAVAGE FLUID; INDUCED LUNG INJURY; FUNCTIONAL-CHARACTERIZATION; GENE-EXPRESSION; HEPATIC ISCHEMIA/REPERFUSION; INFLAMMATORY MEDIATORS; MONOCLONAL-ANTIBODY; BACTERIAL PNEUMONIA; REPERFUSION INJURY;
Keywords:
respiratory distress syndrome; adult; neutrophiles; chemotactic factors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Beck, G Univ Klinikum Mannheim, Inst Anasthesiol & Operat Intens Med, Theodor Kutzer Ufer 1-3, D-68167 Mannheim, Germany Univ Klinikum Mannheim Theodor Kutzer Ufer 1-3 Mannheim Germany D-68167
Citazione:
G. Beck e D. von Zabern, "Role of CXC-chemokines in the pathogenesis of the acute respiratory distress syndrome", ANASTH INTM, 42, 2001, pp. 671-679

Abstract

The recruitment of leukocytes is a hallmark during an inflammatory response in the lung. Chemokines, together with adhesion molecules, cytokines, andproteases, are essential for this directed migration into the inflamed tissue. Over 40 different chemokines have been characterized and classed in tofour subfamilies. Each chemokine causes chemotactic behaviour in specific subpopulations of inflammatory cells. In the pathogenesis of the acute respiratory distress syndrome (ARDS), the polymorphonuclear leukocytes (PMN) seem to play a crucial role. After their activation, they damage the alveolo-capillary membrane via adherence to the stimulated endothelium and alteration of the endothelial permeability. A synopsis of structure, biology and pathobiology of the CXC-chemokine-family, especially chemoattractant for PMN,and their role in the pathogenesis of ARDS is the topic of this mini-review.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:48:45