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Titolo:
Type II pneumocyte-CD8+T-cell interactions - Relationship between target cell cytotoxicity and activation
Autore:
Zhao, MQ; Amir, MK; Rice, WR; Enelow, RI;
Indirizzi:
Univ Virginia, Sch Med, Hlth Syst, Dept Med, Charlottesville, VA 22908 USAUniv Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ Virginia, Sch Med, Beirne Carter Ctr Immunol Res, Charlottesville, VA22908 USA Univ Virginia Charlottesville VA USA 22908 , Charlottesville, VA22908 USA Childrens Hosp, Ctr Med, Cincinnati, OH USA Childrens Hosp Cincinnati OH USA drens Hosp, Ctr Med, Cincinnati, OH USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
fascicolo: 3, volume: 25, anno: 2001,
pagine: 362 - 369
SICI:
1044-1549(200109)25:3<362:TIPI-R>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; CD8(+) T-CELLS; INDUCED PULMONARY FIBROSIS; MEDIATED CYTOTOXICITY; LUNG-DISEASE; INFLUENZA-VIRUS; FAS LIGAND; PERFORIN; EXPRESSION; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Enelow, RI Univ Virginia, Sch Med, Hlth Syst, Dept Med, Box 800546, Charlottesville, VA 22908 USA Univ Virginia Box 800546 Charlottesville VA USA 22908 22908 USA
Citazione:
M.Q. Zhao et al., "Type II pneumocyte-CD8+T-cell interactions - Relationship between target cell cytotoxicity and activation", AM J RESP C, 25(3), 2001, pp. 362-369

Abstract

CD8+ T-cell responses play an important role in the clearance of respiratory virus infection, but may also contribute to lung injury in the process. The effector mechanisms involved in viral clearance and associated lung injury include both cytolytic and noncytolytic effector functions. Previously we have shown that CD8+ T-cell recognition of alveolar epithelial cells triggers chemokine expression by the epithelial cell and that this plays an important role in the inflammatory infiltration that ensues in the context ofT cell-mediated injury (Zhao and colleagues, J. Clin. Invest. 2000;106:R49-R58). In the present study we sought to understand the relationship between alveolar cell cytotoxicity and chemokine expression, both of which occur as a result of CD8+ T-cell antigen recognition. Alveolar epithelial cells efficiently process and present overlapping viral epitopes, and CD8+ T-cell recognition of these class I major histocompatibility complex-restricted epitopes resulted in cytotoxicity of the alveolar cells by both wild-type andperforin-deficient T cells. However, the contribution of perforin-mediatedlysis to the total cytotoxicity of alveolar cells by CD8+ T cells was minimal, and the majority of the lysis was attributable to tumor necrosis factor-a expressed by the T cell. CD8+ T-cell recognition also led to activationof nuclear factor-kappaB in the alveolar epithelial target cells, at levels inversely proportional to the effector/target (E:T) ratio. Finally, at varying E:T ratios, we demonstrated an inverse relationship between alveolar cell cytotoxicity and monocyte chemotactic protein-1 expression, both of which occur as a result of T-cell recognition. These findings may have important ramifications in understanding the relationship between viral clearanceand lung injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:57:59