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Titolo:
Effects of hypotension and fluid depletion on central angiotensin-induced thirst and salt appetite
Autore:
Thunhorst, RL; Johnson, AK;
Indirizzi:
Univ Iowa, Dept Psychol, Iowa City, IA 52242 USA Univ Iowa Iowa City IA USA 52242 a, Dept Psychol, Iowa City, IA 52242 USA Univ Iowa, Dept Pharmacol, Iowa City, IA 52242 USA Univ Iowa Iowa City IAUSA 52242 Dept Pharmacol, Iowa City, IA 52242 USA Univ Iowa, Dept Exercise Sci, Iowa City, IA 52242 USA Univ Iowa Iowa CityIA USA 52242 pt Exercise Sci, Iowa City, IA 52242 USA Univ Iowa, Ctr Cardiovasc, Iowa City, IA 52242 USA Univ Iowa Iowa City IAUSA 52242 Ctr Cardiovasc, Iowa City, IA 52242 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 281, anno: 2001,
pagine: R1726 - R1733
SICI:
0363-6119(200111)281:5<R1726:EOHAFD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SODIUM APPETITE; RENIN-ANGIOTENSIN; INTRACEREBROVENTRICULAR ANGIOTENSIN; URINARY RESPONSES; COLLOID TREATMENT; BLOOD-PRESSURE; RAT-BRAIN; DRINKING; SYSTEM; MODULATION;
Keywords:
minoxidil; captopril; rats; urine volume; water balance; sodium excretion; sodium balance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Thunhorst, RL Univ Iowa, Dept Psychol, 11 Seashore Hall E, Iowa City, IA 52242 USA Univ Iowa 11 Seashore Hall E Iowa City IA USA 52242 2242 USA
Citazione:
R.L. Thunhorst e A.K. Johnson, "Effects of hypotension and fluid depletion on central angiotensin-induced thirst and salt appetite", AM J P-REG, 281(5), 2001, pp. R1726-R1733

Abstract

We examined the effects of hypotension and fluid depletion on water and sodium ingestion in rats in response to intracerebroventricular infusions of ANG II. Hypotension was produced by intravenous infusion of the vasodilatordrug minoxidil (25 mug.kg(-1).min(-1)) concurrently with the angiotensin-converting enzyme inhibitor captopril (0.33 mg/min) to prevent endogenous ANG II formation. Hypotension increased water intake in response to intracerebroventricular ANG II (30 ng/h) but not intake of 0.3 M NaCl solution and caused significant urinary retention of water and sodium. Acute fluid depletion was produced by subcutaneous injections of furosemide (10 mg/kg body wt) either alone or with captopril (100 mg/kg body wt sc) before intracerebroventricular ANG II (15 or 30 ng/h) administration. Fluid depletion increased water intake in response to the highest dose of intracerebroventricular ANG II but did not affect saline intake. In the presence of captopril, fluiddepletion increased intakes of both water and saline in response to both doses of intracerebroventricular ANG II. Because captopril administration causes hypotension in fluid-depleted animals, the results of the two experiments suggest that hypotension in fluid-replete animals preferentially increases water intake in response to intracerebroventricular ANG II and in fluid-depleted animals increases both salt and water intake in response to intracerebroventricular ANG II.

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Documento generato il 27/09/20 alle ore 07:15:53