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Titolo:
Selective effect of tempol on renal medullary hemodynamics in spontaneously hypertensive rats
Autore:
Feng, MG; Dukacz, SAW; Kline, RL;
Indirizzi:
Univ Western Ontario, Dept Physiol, London, ON N6A 5C1, Canada Univ Western Ontario London ON Canada N6A 5C1 London, ON N6A 5C1, Canada
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 281, anno: 2001,
pagine: R1420 - R1425
SICI:
0363-6119(200111)281:5<R1420:SEOTOR>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL BLOOD-PRESSURE; NITRIC-OXIDE SYNTHASE; SODIUM-EXCRETION; OXIDATIVE STRESS; FLOW; SUPEROXIDE; CAPTOPRIL; NATRIURESIS; ENDOTHELIUM; ANGIOTENSIN;
Keywords:
arterial pressure; nitric oxide; renal medulla; kidney; hypertension; angiotensin II;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Kline, RL Univ Western Ontario, Dept Physiol, Med Sci Bldg, London, ON N6A5C1, Canada Univ Western Ontario Med Sci Bldg London ON Canada N6A 5C1 anada
Citazione:
M.G. Feng et al., "Selective effect of tempol on renal medullary hemodynamics in spontaneously hypertensive rats", AM J P-REG, 281(5), 2001, pp. R1420-R1425

Abstract

The present study assessed the short- and long-term effect of tempol, a membrane-permeable mimetic of superoxide dismutase, on renal medullary hemodynamics in spontaneously hypertensive rats (SHR). Tempol was given in the drinking water (1 mM) for 4 days or 7 wk (4-11 wk of age), and medullary blood flow (MBF) was measured over a wide range of renal arterial pressure by means of laser-Doppler flowmetry in anesthetized rats. In addition, the response of the medullary circulation to angiotensin II (5-50 ng . kg(-1) . min(-1) iv) was determined in SHR treated for 4 days with tempol. Compared with control SHR, short- and long-term treatment with tempol decreased arterial pressure by similar to 20 mmHg and increased MBF by 35-50% without altering total renal blood flow (RBF) or autoregulation of RBF. Angiotensin II decreased RBF and MBF dose dependently (similar to 30% at the highest dose) in control SHR. In SHR treated with tempol, angiotensin II decreased RBF (similar to 30% at the highest dose) but did not alter MBF significantly. These data indicate that the antihypertensive effect of short- and long-term administration of tempol in SHR is associated with a selective increase in MBF. Tempol also reduced the sensitivity of MBF to angiotensin II. Taken together, these data support the idea that tempol enhances vasodilator mechanisms of the medullary circulation, possibly by interacting with the nitric oxide system. Increased MBF and reduced sensitivity of MBF to angiotensin II may contribute to the antihypertensive action of tempol in SHR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:23:23