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Titolo:
Role of endogenous PACAP in catecholamine secretion from the rat adrenal gland
Autore:
Fukushima, Y; Hikichi, H; Mizukami, K; Nagayama, T; Yoshida, M; Suzuki-Kusaba, M; Hisa, H; Kimura, T; Satoh, S;
Indirizzi:
Tohoku Univ, Grad Sch Pharmaceut Sci, Pharmacol Lab, Sendai, Miyagi 9808578, Japan Tohoku Univ Sendai Miyagi Japan 9808578 ab, Sendai, Miyagi 9808578, Japan Nippon Dent Univ Sch Dent, Dept Dent Pharmacol, Niigata 9518580, Japan Nippon Dent Univ Sch Dent Niigata Japan 9518580 , Niigata 9518580, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 281, anno: 2001,
pagine: R1562 - R1567
SICI:
0363-6119(200111)281:5<R1562:ROEPIC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLASE-ACTIVATING POLYPEPTIDE; ADENYLATE-CYCLASE; CHROMAFFIN CELLS; ANESTHETIZED DOGS; CALCIUM CHANNELS; BINDING-SITES; PITUITARY; RECEPTORS; VIP; ANTAGONIST;
Keywords:
transmural electrical stimulation; acetylcholine; pituitary adenylate cyclase-activating polypeptide receptor antagonists; pituitary adenylate cyclase-activating polypeptide-(6-38); adrenal chromaffin cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Hisa, H Tohoku Univ, Grad Sch Pharmaceut Sci, Pharmacol Lab, Sendai, Miyagi 9808578, Japan Tohoku Univ Sendai Miyagi Japan 9808578 ai, Miyagi 9808578, Japan
Citazione:
Y. Fukushima et al., "Role of endogenous PACAP in catecholamine secretion from the rat adrenal gland", AM J P-REG, 281(5), 2001, pp. R1562-R1567

Abstract

We elucidated the contribution of endogenous pituitary adenylate cyclase-activating polypeptide (PACAP) to neurally evoked catecholamine secretion from the isolated perfused rat adrenal gland. Infusion of PACAP (100 nM) increased adrenal epinephrine and norepinephrine output. The PACAP-induced catecholamine output responses were inhibited by the PACAP type I receptor antagonist PACAP( 6-38) (30-3,000 nM) but were resistant to the PACAP type II receptor antagonist [Lys(1), Pro(2,5), Ara(3,4),Tyr(6)]- vasoactive intestinal peptide (LPAT-VIP; 30-3,000 nM). Transmural electrical stimulation (ES; 1-10 Hz) or infusion of ACh (6-200 nM) increased adrenal epinephrine and norepinephrine output. PACAP-(6-38) (3,000 nM), but not LPAT-VIP, also inhibited the ES-induced catecholamine output responses. However, PACAP-(6-38) did not affect the ACh-induced catecholamine output responses. PACAP at low concentrations (0.3-3 nM), which had no influence on catecholamine output, enhanced the ACh-induced catecholamine output responses, but not the ES-induced catecholamine output responses. These results suggest that PACAP is released from the nerve endings to facilitate the neurally evoked catecholamine secretion through PACAP type I receptors in the rat adrenal gland.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 09:39:31