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Titolo:
Centrally administered neuropeptide Y delays gastric emptying via Y-2 receptors in rats
Autore:
Ishiguchi, T; Amano, T; Matsubayashi, H; Tada, H; Fujita, M; Takahashi, T;
Indirizzi:
Wakayama Med Coll, Dept Internal Med, Wakayama 6410012, Japan Wakayama MedColl Wakayama Japan 6410012 al Med, Wakayama 6410012, Japan Hiroshima Univ, Sch Med, Dept Pharmacol, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 armacol, Hiroshima 7348551, Japan Duke Univ, Med Ctr, Dept Surg, Durham, NC 27705 USA Duke Univ Durham NC USA 27705 v, Med Ctr, Dept Surg, Durham, NC 27705 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 281, anno: 2001,
pagine: R1522 - R1530
SICI:
0363-6119(200111)281:5<R1522:CANYDG>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; MYOELECTRIC ACTIVITY; NERVOUS-SYSTEM; BILE SECRETION; VAGAL CONTROL; PEPTIDE-YY; MOTILITY; CONTRACTIONS; POLYPEPTIDE; PATTERN;
Keywords:
anorexia nervosa; dorsal vagal complex; migrating motor complex; vagus nerve;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, T Durham VA Med Ctr, Surg Serv 112, Durham, NC 27705 USA DurhamVA Med Ctr Durham NC USA 27705 , Durham, NC 27705 USA
Citazione:
T. Ishiguchi et al., "Centrally administered neuropeptide Y delays gastric emptying via Y-2 receptors in rats", AM J P-REG, 281(5), 2001, pp. R1522-R1530

Abstract

It has been shown that centrally administered neuropeptide Y (NPY) delays gastric emptying. To determine the receptor subtypes of NPY mediating the inhibitory effects on gastric emptying, effects of intracerebroventricular injection of NPY, [Leu(31),Pro(34)]NPY (a Y-1 agonist) and NPY-(3-36) (a Y-2agonist) on solid gastric emptying and postprandial antropyloric motility were studied in conscious rats. Intracerebroventricular injection of NPY and NPY-(3-36), but not [Leu(31),Pro(34)] NPY, delayed solid gastric emptyingin a dose-dependent manner (0.03-3 nmol). After the feeding (40 min), contractions with low frequency and high amplitude of the antrum were frequently observed, and the peak contraction of the antrum occurred most often 3-6 s before the peak contraction of the pylorus. Intracerebroventricular injection of NPY and NPY-(3-36) (3 nmol), but not [Leu(31),Pro(34)]NPY, significantly reduced antral contractions and the number of antropyloric coordination events. It is suggested that centrally administered NPY impairs postprandial antral contractions and antropyloric coordination via Y-2 receptors, resulting in delayed gastric emptying.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 02:01:23