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Titolo:
Direct innervation of white fat and adrenal medullary catecholamines mediate photoperiodic changes in body fat
Autore:
Demas, GE; Bartness, TJ;
Indirizzi:
Georgia State Univ, Dept Biol, Ctr Behav Neurosci, Atlanta, GA 30303 USA Georgia State Univ Atlanta GA USA 30303 v Neurosci, Atlanta, GA 30303 USA Georgia State Univ, Dept Psychol, Ctr Behav Neurosci, Atlanta, GA 30303 USA Georgia State Univ Atlanta GA USA 30303 v Neurosci, Atlanta, GA 30303 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 5, volume: 281, anno: 2001,
pagine: R1499 - R1505
SICI:
0363-6119(200111)281:5<R1499:DIOWFA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIBERIAN HAMSTERS; ADIPOSE-TISSUE; HYPOTHALAMIC-STIMULATION; CHEMICAL SYMPATHECTOMY; RAT; MOBILIZATION; LIPOLYSIS; METABOLISM; TURNOVER; WEIGHT;
Keywords:
norepinephrine; adipose tissue; body weight; denervation; sympathetic nervous system; white adipose tissue; Siberian hamsters; sympathectomy; guanethidine; obesity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Bartness, TJ Georgia State Univ, Dept Biol, Ctr Behav Neurosci, 24 Peachtree Ctr Ave NE, Atlanta, GA 30303 USA Georgia State Univ 24 Peachtree Ctr Ave NE Atlanta GA USA 30303
Citazione:
G.E. Demas e T.J. Bartness, "Direct innervation of white fat and adrenal medullary catecholamines mediate photoperiodic changes in body fat", AM J P-REG, 281(5), 2001, pp. R1499-R1505

Abstract

Seasonal adjustments in Siberian hamster adiposity are triggered by day length changes [i.e., short "winter-like" days (SDs) elicit body fat decreases vs. long "summer-like" days (LDs)]. These and other white adipose tissue (WAT) mass decreases traditionally have been ascribed to lipolysis triggered by sympathetically mediated, adrenal medullary released epinephrine; however, recent evidence suggests that direct sympathetic innervation of WAT also is important. Therefore, the contributions of WAT sympathetic innervation and adrenal medullary catecholamines to SD-induced decreases in adipositywere tested. Siberian hamsters were surgically bilaterally adrenal demedullated (ADMEDx) or sham ADMEDx, and all had one inguinal WAT (IWAT) pad sympathectomized via locally injected guanethidine, with the contralateral pad serving as a within-animal innervated control. One-half of the hamsters remained in LDs; the remainder was transferred to SDs. Guanethidine and ADMEDxabolished IWAT norepinephrine and adrenal epinephrine contents, respectively. Although sympathetic denervation or ADMEDx alone did not block SD-induced decreases in IWAT mass, their combination did. These results suggest that both adrenal catecholamines and the sympathetic innervation of WAT interact to decrease SD-induced decreased adiposity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 12:46:09