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Titolo:
Chronic decentralization of the heart differentially remodels canine intrinsic cardiac neuron muscarinic receptors
Autore:
Smith, FM; McGuirt, AS; Hoover, DB; Armour, JA; Ardell, JL;
Indirizzi:
E Tennessee State Univ, James H Quillen Coll Med, Dept Pharmacol, Johnson City, TN 37614 USA E Tennessee State Univ Johnson City TN USA 37614 hnson City, TN 37614 USA Dalhousie Univ, Dept Anat & Neurobiol, Halifax, NS B3H 4H7, Canada Dalhousie Univ Halifax NS Canada B3H 4H7 iol, Halifax, NS B3H 4H7, Canada Dalhousie Univ, Dept Physiol, Halifax, NS B3H 4H7, Canada Dalhousie Univ Halifax NS Canada B3H 4H7 iol, Halifax, NS B3H 4H7, Canada Univ S Alabama, Dept Physiol, Mobile, AL 36688 USA Univ S Alabama Mobile AL USA 36688 ma, Dept Physiol, Mobile, AL 36688 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
fascicolo: 5, volume: 281, anno: 2001,
pagine: H1919 - H1930
SICI:
0363-6135(200111)281:5<H1919:CDOTHD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARASYMPATHETIC GANGLION-CELLS; PIG INTRACARDIAC NEURONS; SYMPATHETIC-GANGLIA; ACETYLCHOLINE SENSITIVITY; NERVOUS-SYSTEM; RAT-HEART; DENERVATION; FROG; SUPERSENSITIVITY; LOCALIZATION;
Keywords:
intracardiac ganglia; intracellular recording; muscarinic receptors; nicotinic receptors; autoradiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Ardell, JL E Tennessee State Univ, James H Quillen Coll Med, Dept Pharmacol, Johnson City, TN 37614 USA E Tennessee State Univ Johnson City TN USA 37614 TN 37614 USA
Citazione:
F.M. Smith et al., "Chronic decentralization of the heart differentially remodels canine intrinsic cardiac neuron muscarinic receptors", AM J P-HEAR, 281(5), 2001, pp. H1919-H1930

Abstract

The objective of the study was to determine if chronic interruption of allextrinsic nerve inputs to the heart alters cholinergic-mediated responses within the intrinsic cardiac nervous system (ICN). Extracardiac nerve inputs to the ICN were surgically interrupted (ICN decentralized). Three weeks later, the intrinsic cardiac right atrial ganglionated plexus (RAGP) was removed and intrinsic cardiac neuronal responses were evaluated electrophysiologically. Cholinergic receptor abundance was evaluated using autoradiography. In sham controls and chronic decentralized ICN ganglia, neuronal postsynaptic responses were mediated by acetylcholine, acting at nicotinic and muscarinic receptors. Muscarine-but not nicotine-mediated synaptic responses that were enhanced after chronic ICN decentralization. After chronic decentralization, muscarine facilitation of orthodromic neuronal activation increased. Receptor autoradiography demonstrated that nicotinic and muscarinic receptor density associated with the RAGP was unaffected by decentralization and that muscarinic receptors were tenfold more abundant than nicotinic receptors in the right atrial ganglia in each group. After chronic decentralization of the ICN, intrinsic cardiac neurons remain viable and responsive tocholinergic synaptic inputs. Enhanced muscarinic responsiveness of intrinsic cardiac neurons occurs without changes in receptor abundance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:20:24