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Titolo:
Synthesis of hepatic secretory proteins in normal adults consuming a diet marginally adequate in protein
Autore:
Jackson, AA; Phillips, G; McClelland, I; Jahoor, F;
Indirizzi:
Univ Southampton, Inst Human Nutr, Southampton SO16 6YD, Hants, England Univ Southampton Southampton Hants England SO16 6YD 6 6YD, Hants, England Baylor Univ, USDA ARS, Childrens Nutr Res Ctr, Houston, TX 77030 USA Baylor Univ Houston TX USA 77030 rens Nutr Res Ctr, Houston, TX 77030 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 5, volume: 281, anno: 2001,
pagine: G1179 - G1187
SICI:
0193-1857(200111)281:5<G1179:SOHSPI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-A-I; RAT SERUM-ALBUMIN; ACUTE-PHASE; AMINO-ACIDS; HEART-DISEASE; HEPG2 CELLS; METABOLISM; PLASMA; INFLAMMATION; BIOSYNTHESIS;
Keywords:
protein synthesis; phenylalanine; albumin; transthyretin; very low-density lipoprotein apolipoprotein B-100; high-density lipoprotein apolipoprotein A-1; fibrinogen; alpha 1-antitrypsin; haptoglobin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Jackson, AA Univ Southampton, Southampton Gen Hosp, Inst Human Nutr, LevelC 113 W Wing,Tremona Rd, Southampton SO16 6YD, Hants, England Univ Southampton Level C 113 W Wing,Tremona Rd Southampton Hants England SO16 6YD
Citazione:
A.A. Jackson et al., "Synthesis of hepatic secretory proteins in normal adults consuming a diet marginally adequate in protein", AM J P-GAST, 281(5), 2001, pp. G1179-G1187

Abstract

The plasma concentration and hepatic synthesis rates of albumin, transthyretin, very low-density lipoprotein apolipoprotein B-100 (VLDL-apoB-100), high-density lipoprotein apolipoprotein A-1, fibrinogen, alpha1-antitrypsin, and haptoglobin were measured in six normal adults before and after consuming a protein intake of 0.6 g . kg body wt(-1) . day(-1) for 7 days. The synthesis of hepatic proteins was measured from the incorporation of [H-2(5)] phenylalanine, following prime/continuous infusion, using plasma VLDL-apoB-100 isotopic enrichment to represent the precursor pool. Synthesis of albumin declined by 50% (P< 0.001) following the lower-protein diet, VLDL-apoB-100 declined by 20% (P< 0.001), and apoA-1 declined by 16% (P< 0.05). By contrast, synthesis increased for fibrinogen (50%, P< 0.05) and haptoglobin (90%, P< 0.001). This pattern of change, with decreased synthesis of nutrienttransport proteins and increased formation of acute-phase proteins, suggestive of a low-grade inflammatory response, was accompanied by increased plasma concentration of the inflammatory cytokine interleukin 6 (30%, P< 0.05). The pattern of change in the synthesis of hepatic secretory proteins following 7 days on the low-protein diet may be of functional relevance for lipid transport and the capacity to cope with stress.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 10:45:40