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Titolo:
Mechanisms of reflexes induced by esophageal distension
Autore:
Lang, IM; Medda, BK; Shaker, R;
Indirizzi:
Med Coll Wisconsin, Dysphagia Inst, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 a Inst, Milwaukee, WI 53226 USA Med Coll Wisconsin, Div Gastroenterol & Hepatol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 epatol, Milwaukee, WI 53226 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 5, volume: 281, anno: 2001,
pagine: G1246 - G1263
SICI:
0193-1857(200111)281:5<G1246:MORIBE>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ESOPHAGOGLOTTAL CLOSURE REFLEX; VAGAL AFFERENT-FIBERS; SPHINCTER RELAXATIONS; AIRWAY PROTECTION; CAT; MECHANORECEPTORS; RESPONSES; IDENTIFICATION; INNERVATION; CAPSAICIN;
Keywords:
secondary peristalsis; belching; swallowing; capsaicin; baclofen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Lang, IM Med Coll Wisconsin, Dysphagia Res Lab, 8701 Watertown Plank Rd, Milwaukee,WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd Milwaukee WI USA 53226
Citazione:
I.M. Lang et al., "Mechanisms of reflexes induced by esophageal distension", AM J P-GAST, 281(5), 2001, pp. G1246-G1263

Abstract

We investigated the mechanisms of esophageal distension-induced reflexes in decerebrate cats. Slow air esophageal distension activated esophago-upperesophageal sphincter (UES) contractile reflex (EUCR) and secondary peristalsis (2P). Rapid air distension activated esophago-UES relaxation reflex (EURR), esophago-glottal closure reflex (EGCR), esophago-hyoid distraction reflex (EHDR), and esophago-esophagus contraction reflex (EECR). Longitudinalesophageal stretch did not activate these reflexes. Magnitude and timing of EUCR were related to 2P but not injected air volume. Cervical esophagus transection did not affect the threshold of any reflex. Bolus diversion prevented swallow-related esophageal peristalsis. Lidocaine or capsaicin esophageal perfusion, esophageal mucosal layer removal, or intravenous baclofen blocked or inhibited EURR, EGCR, EHDR, and EECR but not EUCR or 2P. Thoracicvagotomy blocked all reflexes. These six reflexes can be activated by esophageal distension, and they occur in two sets depending on inflation rate rather than volume. EUCR was independent of 2P, but 2P activated EUCR; therefore, EUCR may help prevent reflux during peristalsis. All esophageal peristalsis may be secondary to esophageal stimulation in the cat. EURR, EHDR, EGCR, and EECR may contribute to belching and are probably mediated by capsaicin-sensitive, rapidly adapting mucosal mechanoreceptors. GABA-B receptorsalso inhibit these reflexes. EUCR and 2P are probably mediated by slowly adapting muscular mechanoreceptors. All six reflexes are mediated by vagal afferent fibers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:41:08