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Titolo:
Influence of overload on phenotypic remodeling in regenerated skeletal muscle
Autore:
Bigard, AX; Zoll, J; Ribera, F; Mateo, P; Sanchez, H; Serrurier, B; Ventura-Clapier, R;
Indirizzi:
CRSSA, Unite Bioenerget & Environm, F-38702 La Tronche, France CRSSA La Tronche France F-38702 t & Environm, F-38702 La Tronche, France Univ Paris Sud, INSERM, U446, Fac Pharm, Chatenay Malabry, France Univ Paris Sud Chatenay Malabry France Pharm, Chatenay Malabry, France
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
fascicolo: 5, volume: 281, anno: 2001,
pagine: C1686 - C1694
SICI:
0363-6143(200111)281:5<C1686:IOOOPR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOSIN HEAVY-CHAIN; SARCOPLASMIC-RETICULUM; CELLULAR ADAPTATION; EXPRESSION; RAT; ISOFORMS; FIBERS; GRAFTS; GENE; CONTRACTILE;
Keywords:
compensatory overload; myosin heavy chain; creatine kinase; lactate dehydrogenase; SERCA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Bigard, AX CRSSA, Unite Bioenerget & Environm, BP 87, F-38702 La Tronche, France CRSSA BP 87 La Tronche France F-38702 38702 La Tronche, France
Citazione:
A.X. Bigard et al., "Influence of overload on phenotypic remodeling in regenerated skeletal muscle", AM J P-CELL, 281(5), 2001, pp. C1686-C1694

Abstract

We studied the effects of 10 wk of functional overload on the expression of myosin heavy chain (MHC), sarcoplasmic reticulum Ca2+-ATPase isoforms (SERCA), and the activity of several metabolic enzymes in sham and regeneratedplantaris muscles. Overload was accomplished by bilateral surgical ablation of its synergists 4 wk after right plantaris muscles regenerated after myotoxic infiltration. The overload-induced muscle enlargement was slightly less in regenerated than in sham muscles [28% (P< 0.005) and 43% (P< 0.001),respectively]. Overload led to an increase in type I MHC expression (P< 0.01) to a similar extent in sham and regenerated plantaris, while the expected shift from type IIb to type IIa MHC was less marked in regenerated than in sham plantaris. The overload-induced decrease in the expression of the fast SERCA isoform and in the activity of the M subunit of lactate dehydrogenase occurred to a similar extent in sham and regenerated plantaris [66% (P< 0.01) and 27% (P< 0.005), respectively]. In conclusion, the lesser responses of muscle mass and fast MHC composition of regenerated plantaris to mechanical overload suggest an alteration of the transcriptional, translational, and/or posttranslational control of gene expression in regenerated muscle.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 07:42:46