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Titolo:
Spontaneous pregnancy-induced hypertension and intrauterine growth restriction in rats
Autore:
Sharkey, LC; McCune, SA; Yuan, O; Lange, C; Fray, J;
Indirizzi:
Univ Massachusetts, Sch Med, Genom Physiol Grp, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 ol Grp, Worcester, MA 01655 USA Tufts Univ, Sch Vet Med, Dept Biomed Sci, Grafton, MA USA Tufts Univ Grafton MA USA Sch Vet Med, Dept Biomed Sci, Grafton, MA USA Ohio State Univ, Dept Food Sci & Technol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 i & Technol, Columbus, OH 43210 USA AlphaGene Inc, Woburn, MA USA AlphaGene Inc Woburn MA USAAlphaGene Inc, Woburn, MA USA
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 10, volume: 14, anno: 2001,
pagine: 1058 - 1066
SICI:
0895-7061(200110)14:10<1058:SPHAIG>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
DENSITY-LIPOPROTEIN RECEPTOR; NITRIC-OXIDE INHIBITION; MOLECULAR-CLONING; L-ARGININE; BLOOD-PRESSURE; ENCODING HUMAN; CDNA CLONING; PREECLAMPSIA; GENE; EXPRESSION;
Keywords:
severe preeclampsia; pregnancy-associated hypertension; SHHF/Mcc-fa(cp) rats; small for gestational age offsprings; microarray analysis; low birth weight; gene expression profiling; post-translational modifications; PROSITE; angiotensinogen;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Fray, J Univ Massachusetts, Sch Med, Genom Physiol Grp, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 Worcester, MA 01655 USA
Citazione:
L.C. Sharkey et al., "Spontaneous pregnancy-induced hypertension and intrauterine growth restriction in rats", AM J HYPERT, 14(10), 2001, pp. 1058-1066

Abstract

The SHHF/Mcc-fa(cp) (spontaneous hypertension and heart failure) rat is advanced as a novel and suitable non-primate model of pregnancy-associated hypertension and fetal growth restriction because it simultaneously has spontaneous pregnancy-associated hypertension, small for gestational age (SGA) offsprings, and altered placental gene expression. Pregnancy-associated hypertension is a major contributor to maternal and fetal morbidity and mortality with the potential to result in maternal death and the need for iatrogenic preterm. delivery. It has been reported to develop spontaneously in humans, but not in animals; consequently, progress in identifying the cause andpathogenesis of this disorder has been hampered. Spontaneous hypertension and heart failure rats develop hypertension spontaneously as they age, therefore we sought to determine whether these rats developed hypertension and SGA offsprings during pregnancy. Our results show that systolic blood pressure (BP) increased >40 mm Hg by the end of the first trimester and remainedat this elevated level for the remainder of pregnancy, but decreased afterparturition. Placenta weights of SHHF rats (0.60 +/- 0.02 g, n = 36) were significantly higher than Wistar-Kyoto (WKY) rats (0.42 +/- 0.01 g, n = 22,P < .05), but pup weights were significantly lower (2.68 <plus/minus> 0.06g for SHHF rats compared to 3.24 +/- 0.06 g for WKY controls, P < .05). Histologic examination revealed pathologic lesions in neither heart, liver, placenta, nor kidney. L-Arginine administered in drinking water prevented the elevation of BP, particularly during the third trimester. Placentas from SHHF rats displayed altered expression of several genes whose protein products have been implicated in preeclampsia, including serotonin receptor, sodium channel, carbonic anhydrase, estrogen receptor regulator, major histocompatibility complex proteins, superoxide dismutase, and angiotensiogen. In addition, gene expression profiling showed alteration of a number of subcellular putative myristoylproteins not previously associated with preeclampsia, particularly those engaged in post-translational modifications in the placenta. Thus, SHHF rats may be a valuable tool, because it simultaneously has spontaneous pregnancy-associated hypertension, SGA offsprings, and altered placental gene expression. Am J Hypertens 2001;14:1058-1066 (C) 2001 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:29:23