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Titolo:
Independent association of plasma leptin levels and left ventricular isovolumic relaxation in uncomplicated hypertension
Autore:
Galderisi, M; Tagliamonte, MR; DErrico, A; Carella, C; Varricchio, G; Mondillo, S; de Divitiis, O; Paolisso, G;
Indirizzi:
Univ Naples Federico II, Cattedra Med Urgenza, Dipartimento Med Clin & Sperimentale, Naples, Italy Univ Naples Federico II Naples Italy Clin & Sperimentale, Naples, Italy Ist Endocrinol, Dipartimento Gerontol Geriatria & Malattie Metab, Naples, Italy Ist Endocrinol Naples Italy l Geriatria & Malattie Metab, Naples, Italy Seconda Univ Napoli, Cattedra Geriatria, Dipartimento Gerontol Geriatria &Malattie Metab, I-80138 Naples, Italy Seconda Univ Napoli Naples Italy I-80138 ie Metab, I-80138 Naples, Italy Univ Siena, Ist Clin Med, I-53100 Siena, Italy Univ Siena Siena Italy I-53100 Siena, Ist Clin Med, I-53100 Siena, Italy
Titolo Testata:
AMERICAN JOURNAL OF HYPERTENSION
fascicolo: 10, volume: 14, anno: 2001,
pagine: 1019 - 1024
SICI:
0895-7061(200110)14:10<1019:IAOPLL>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; DIASTOLIC DYSFUNCTION; INSULIN-RESISTANCE; SYSTOLIC FUNCTION; BODY-COMPOSITION; BLOOD-PRESSURE; OBESE GENE; GLUCOSE; HYPERGLYCEMIA; HYPERTROPHY;
Keywords:
leptin; insulin resistance; arterial hypertension; diastole; Doppler echocardiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Paolisso, G Seconda Univ Napoli, Cattedra Geriatria, Dipartimento GerontolGeriatria &Malattie Metab, Piazza Miraglia 2, I-80138 Naples, Italy Seconda Univ Napoli Piazza Miraglia 2 Naples Italy I-80138 ly
Citazione:
M. Galderisi et al., "Independent association of plasma leptin levels and left ventricular isovolumic relaxation in uncomplicated hypertension", AM J HYPERT, 14(10), 2001, pp. 1019-1024

Abstract

Background: On the basis of evidence of plasma leptin (LE) effects on cardiovascular system, we assessed possible association of LE and Doppler-derived left ventricular (LV) diastolic function in arterial hypertension. Methods: Doppler echocardiography, blood sample for fasting plasma LE levels, and euglycemic hyperinsulinemic glucose clamp were performed on 15 healthy insulin-sensitive men and 40 newly diagnosed hypertensive men, who weredivided into two groups according to insulin sensitivity degree: 15 insulin sensitive (IS) and 25 insulin resistant (IR) individuals (whole body glucose disposal >33.3 and <33.3 <mu>mol/kg, respectively). Results: The IR hypertensives had significantly higher body mass index (BMI), waist/hip ratio, LE and LV mass index than the other two groups. IR hypertensives had lower LE (even after adjusting for BMI and waist/hip ratio) and among LV diastolic indexes, lower E peak velocity (P < .05) and longer isovolumic relaxation time (IVRT) (P < .001) in comparison to IR hypertensives. IR hypertensives had the lowest E/A ratio (0.88 +/- 0.2) compared to IS patients (1.03 +/- 0.1 P < .05) and controls (1.31 <plus/minus> 10.2 P < .001). By multiple linear regression analyses performed both in the overallpopulation and hypertensives, LV mass index and LE were independently associated to IVRT (R-2 = 0.41 in overall population, R-2 = 0.42 in hypertensives, both P < .0001), whereas age, heart rate, diastolic and systolic blood pressure (BP), BMI, waist/hip ratio, and insulin action were not significant. Conclusions: Our study underscores an independent association of increasedplasma LE and lengthening of isovolumic relaxation in uncomplicated hypertension. Further studies will need to understand the conditions underlying both these phenomena. Am J Hypertens 2001;14: 1019-1024 (C) 2001 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:13:23