Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Early coronary intervention following pharmacologic therapy for acute myocardial infarction - (The combined TIMI 10B-TIMI 14 experience)
Autore:
Schweiger, MJ; Cannon, CP; Murphy, SA; Gibson, CM; Cook, JR; Giugliano, RP; Changezi, HU; Antman, EM; Braunwald, E;
Indirizzi:
Baystate Med Ctr, Div Cardiol, Dept Med, Springfield, MA 01199 USA Baystate Med Ctr Springfield MA USA 01199 Med, Springfield, MA 01199 USA Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 Dept Med, Boston, MA 02115 USA Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA Univ CalifSan Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
AMERICAN JOURNAL OF CARDIOLOGY
fascicolo: 8, volume: 88, anno: 2001,
pagine: 831 - 836
SICI:
0002-9149(20011015)88:8<831:ECIFPT>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
TISSUE-PLASMINOGEN-ACTIVATOR; PRACTICE GUIDELINES COMMITTEE; ASSOCIATION TASK-FORCE; RESCUE ANGIOPLASTY; THROMBOLYTIC THERAPY; ACC/AHA GUIDELINES; RANDOMIZED TRIAL; ARTERY STENTS; 4 TRIAL; MANAGEMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Schweiger, MJ Baystate Med Ctr, Div Cardiol, Dept Med, 759 Chestnut St, Springfield, MA 01199 USA Baystate Med Ctr 759 Chestnut St Springfield MA USA01199 SA
Citazione:
M.J. Schweiger et al., "Early coronary intervention following pharmacologic therapy for acute myocardial infarction - (The combined TIMI 10B-TIMI 14 experience)", AM J CARD, 88(8), 2001, pp. 831-836

Abstract

Earlier studies have suggested that immediate percutaneous coronary intervention (PCI) following thrombolytic therapy for acute myocardial infarction(AMI) is associated with an increase in adverse events and that routine PCI in this setting has offered no advantage over a conservative strategy. Toreassess this issue in a more recent era, we evaluated 1,938 patients fromthe Thrombolysis in Myocardial Infarction (TIMI) 10B and 14 trials of AMI. Patients in TIMI 10B were randomized to receive tissue plasminogen activator or TNK tissue plasminogen activator, whereas patients in TIMI 14B trial were randomized to receive thrombolytic therapy with or without abciximab. All patients underwent angiography 90 minutes after receiving pharmacologictherapy. Patients who underwent PCI were classified as having undergone a rescue procedure (TIMI 0 or 1 flow at 90 minutes), an adjunctive procedure (TIMI 2 or 3 flow at 90 minutes), or a delayed procedure (performed > 150 minutes after symptom onset, median of 2.75 days). Among patients with TIN 0or 1 flow, there was a trend for lower 30-day mortality among patients whounderwent rescue PCI than among those who did not (6% vs 17%, p = 0.01, adjusted p = 0.28). Patients who underwent adjunctive PCI had similar 30-day mortality and/or reinfarction as those who underwent delayed PCI. In a multivariate model both had lower 30-day mortality and/or reinfarction than patients with "successful thrombolysis" (i.e., TIMI 3 flow at 90 minutes) who did not undergo revascularization (p = 0.02). Thus, early PCI following AMIis associated with excellent outcomes. Randomized trials of an early invasive strategy following thrombolysis are warranted. (C) 2001 by Excerpta Medica, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 08:03:13