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Titolo:
Haloperidol reduces stimulant and reinforcing effects of ethanol in socialdrinkers
Autore:
Enggasser, JL; de Wit, H;
Indirizzi:
Univ Chicago, Dept Psychiat, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 o, Dept Psychiat, Chicago, IL 60637 USA
Titolo Testata:
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
fascicolo: 10, volume: 25, anno: 2001,
pagine: 1448 - 1456
SICI:
0145-6008(200110)25:10<1448:HRSARE>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; FREELY MOVING RATS; NUCLEUS-ACCUMBENS; INDIVIDUAL-DIFFERENCES; DOPAMINERGIC-NEURONS; SUBJECTIVE RESPONSES; RECEPTOR ANTAGONISTS; LOCOMOTOR-ACTIVITY; HEALTHY HUMANS; ALCOHOL;
Keywords:
ethanol; dopamine; subjective effects; haloperidol; human;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: de Wit, H Univ Chicago, Dept Psychiat, MC3077,5841 S Maryland Ave, Chicago, IL 60637USA Univ Chicago MC3077,5841 S Maryland Ave Chicago IL USA 60637 USA
Citazione:
J.L. Enggasser e H. de Wit, "Haloperidol reduces stimulant and reinforcing effects of ethanol in socialdrinkers", ALC CLIN EX, 25(10), 2001, pp. 1448-1456

Abstract

Background: Despite abundant preclinical support for a role of dopamine (DA) in the stimulant-like and reinforcing effects of ethanol, there have been few studies directly investigating this mechanism in human subjects. Thisstudy examined the effect of a DA antagonist, haloperidol, on the subjective stimulant-like effects of acute doses of ethanol and on ethanol reinforcement in healthy human volunteers. It was hypothesized that a low dose of the DA D-2/D-3 antagonist haloperidol (3 mg) would attenuate stimulant-like subjective effects of ethanol (0.75 g/kg) and reduce the number of drinks chosen during a subsequent choice phase. Methods: Seventeen healthy men and women, 21 to 35 years old, participatedin four laboratory sessions conducted at 1-week intervals. During the foursessions they received, in randomized order under double-blind conditions,capsules containing haloperidol or placebo followed by three drinks containing ethanol (0.75 g/kg) or placebo, at 30-min intervals. Subjective and behavioral responses were measured before and after the beverages. After the third beverage, subjects could choose up to five additional doses of the beverage they had ingested. Results: Haloperidol reduced the number of ethanol beverages subjects chose without altering placebo beverage choices. Haloperidol also dampened someof the subjective effects of ethanol, especially in subjects who experienced stimulation after ethanol. Haloperidol reduced stimulant-like and euphorigenic effects of ethanol in subjects who experienced stimulant effects (n=8) but had no effect in subjects who did not experience stimulation from ethanol (n=9). Conclusions: These findings suggest that DA plays a role in the stimulant-like, euphorigenic, and reinforcing qualities of ethanol in humans. However, the findings also raised new questions about the link between the subjective and reinforcing effects of ethanol.

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Documento generato il 01/04/20 alle ore 23:00:50