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Titolo:
A double-blind randomized placebo-controlled trial of lofexidine in alcohol withdrawal: Lofexidine is not a useful adjunct to chlordiazepoxide
Autore:
Keaney, F; Strang, J; Gossop, M; Marshall, EJ; Farrell, M; Welch, S; Hahn, B; Gonzalez, A;
Indirizzi:
Univ London Kings Coll, Inst Psychiat, Natl Addict Ctr, London SE5 8AF, England Univ London Kings Coll London England SE5 8AF r, London SE5 8AF, England Maudsley Hosp & Inst Psychiat, London SE5 8AF, England Maudsley Hosp & Inst Psychiat London England SE5 8AF on SE5 8AF, England
Titolo Testata:
ALCOHOL AND ALCOHOLISM
fascicolo: 5, volume: 36, anno: 2001,
pagine: 426 - 430
SICI:
0735-0414(200109/10)36:5<426:ADRPTO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
INPATIENT OPIATE DETOXIFICATION; CONVENTIONAL LOFEXIDINE; CLONIDINE; METHADONE; MANAGEMENT; DEPENDENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Keaney, F Univ London Kings Coll, Inst Psychiat, Natl Addict Ctr, 4 Windsor Walk, London SE5 8AF, England Univ London Kings Coll 4 Windsor Walk London England SE5 8AF nd
Citazione:
F. Keaney et al., "A double-blind randomized placebo-controlled trial of lofexidine in alcohol withdrawal: Lofexidine is not a useful adjunct to chlordiazepoxide", ALC ALCOHOL, 36(5), 2001, pp. 426-430

Abstract

Lofexidine is an alpha-adrenoceptor agonist which has proved useful in opiate withdrawal and which, through its attenuation of noradrenergic activity, might be a valuable adjunct in the management of alcohol withdrawal. The objective of this study was to compare the clinical effectiveness and patient retention with adjunctive lofexidine versus placebo in the treatment of alcohol withdrawal under chlordiazepoxide cover. This was done in a prospective double-blind randomized placebo-controlled trial with 72 alcohol-dependent adults referred and admitted for in-patient alcohol detoxification. The adjunctive lofexidine group experienced significantly more severe withdrawal symptoms, greater hypotensive problems, more adverse effects, and no better rates of retention in treatment. Lofexidine provides no discernible benefit as an adjunctive medication (to chlordiazepoxide) in alcohol detoxification and, on the basis of our study, appears to be contra-indicated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:05:57