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Titolo:
Fos-related antigens are involved in the transcriptional responses of locus coeruleus neurons to altered gravitational fields in rats
Autore:
Pompeiano, M; DAscanio, P; Centini, C; Pompeiano, O; Cirelli, C; Tononi, G;
Indirizzi:
Univ Pisa, Dipartimento Fisiol & Biochim, IT-56127 Pisa, Italy Univ Pisa Pisa Italy IT-56127 nto Fisiol & Biochim, IT-56127 Pisa, Italy Univ Pisa, Dipartimento Sci Uomo & Ambiente, Scuola Med, I-56127 Pisa, Italy Univ Pisa Pisa Italy I-56127 & Ambiente, Scuola Med, I-56127 Pisa, Italy
Titolo Testata:
ACTA OTO-LARYNGOLOGICA
, , anno: 2001, supplemento:, 545
pagine: 127 - 132
SICI:
0001-6489(2001):<127:FAAIIT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
C-FOS; DELTA-FOSB; EXPRESSION; CERULEUS; COMPENSATION; PROTEIN; SLEEP; BRAIN; CAT;
Keywords:
Fos-related antigen expression; gravitational responses; immediate early genes; locus coeruleus neurons; Neurolab; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Pompeiano, M Univ Pisa, Dipartimento Fisiol & Biochim, Via S Zeno 31, IT-56127 Pisa, Italy Univ Pisa Via S Zeno 31 Pisa Italy IT-56127 6127 Pisa, Italy
Citazione:
M. Pompeiano et al., "Fos-related antigens are involved in the transcriptional responses of locus coeruleus neurons to altered gravitational fields in rats", ACT OTO-LAR, 2001, pp. 127-132

Abstract

Locus coerulcus (LC) neurons, which have widespread projections to the whole brain, respond to natural stimulation of macular receptors. Using immunocytochemistry we investigated whether rats exposed to altered gravitationalfields showed changes in Fos and Fos-related antigen (FRA) protein levels in the LC. Fos protein is induced very rapidly and returns to basal levels within hours after stimulation, while FRAs persist for days or weeks after induction. Adult male albino rats (Fisher 344) were sacrificed at differenttime points during a space flight (NASA Neurolab Mission, STS-90) and the numbers of Fos- and FRA-positive cells in the LC were counted and compared to those in ground-based control rats. No significant changes in Fos protein expression were detected in the LC under different space flight conditions. In contrast, the number of FRA-positive cells increased on average to 167% of that of the controls at FD2, i.e. when gravity increased from 1 to 3gduring the launch before reaching about Og. FRA-labeled neurons then decreased to 46% of control values at FD14, i.e. after adaptation to Og, but increased again to 317% of control values at R + 1, when the animals were exposed to an increase in gravitational force from 0 to 1.5-1.8g before reaching Ig during landing. The number of labeled cells was 193% of the control values at R + 13, i.e. after readaptation to 1g. Thus gravitational force appears to be very effective in inducing a long-term increase in FRA protein expression in the LC. Because activity in the noradrenergic LC neurons may increase Fos expression in several target structures, we postulate that the long-lasting induction of FRAs in the LC at FD2, and more prominently at R 1, may contribute to the long-term molecular changes which probably occurin the brain during adaptation to Og and readaptation to 1g.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:11:27