Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Permeability of hemato-encephalic barrier in Alzheimer's disease and parkinsonism with cognitive disorders
Autore:
Preobrazhenskaya, IS; Chekhonin, VP; Yakhno, NN;
Indirizzi:
IM Sechenov Med Acad, Dept Nervous Dis, Moscow, Russia IM Sechenov Med Acad Moscow Russia ad, Dept Nervous Dis, Moscow, Russia VP Serbskii Social & Forens Psychiat State Res In, Moscow, Russia VP Serbskii Social & Forens Psychiat State Res In Moscow Russia Russia
Titolo Testata:
ZHURNAL NEVROPATOLOGII I PSIKHIATRII IMENI S S KORSAKOVA
fascicolo: 5, volume: 101, anno: 2001,
pagine: 39 - 42
SICI:
0044-4588(2001)101:5<39:POHBIA>2.0.ZU;2-G
Fonte:
ISI
Lingua:
RUS
Soggetto:
BLOOD-BRAIN-BARRIER; FIBRILLARY ACIDIC PROTEIN; NEURON-SPECIFIC ENOLASE; CEREBROSPINAL-FLUID; APOLIPOPROTEIN-J; AMYLOID-BETA; DEMENTIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Preobrazhenskaya, IS IM Sechenov Med Acad, Dept Nervous Dis, Moscow, Russia IM Sechenov Med Acad Moscow Russia Moscow, Russia
Citazione:
I.S. Preobrazhenskaya et al., "Permeability of hemato-encephalic barrier in Alzheimer's disease and parkinsonism with cognitive disorders", ZH NEVR PS, 101(5), 2001, pp. 39-42

Abstract

The study was made of 17 patients with expected Alzheimer's disease (AD), 29 patients with Parkinson's disease (PD) and 7 with a expected dementia with Levy bodies (DLB). The severity of cognitive disorders was determined according to the following scales: Global Deterioration Rating Scale, Mini-mental State Examination, Mattis Dementia Rating Scale. Besides, the patientsstate was evaluated, in the whole, according to some scales. Permeability of hemato-encephalic barrier was evaluated according to the blood serum levels of 3 neurospecific proteins - neuron specific enolase, glial fibrillaryprotein and alpha-glycoprotein. Their determination was performed by ELISAmethod. The significant elevation of the levels of the proteins studied was found already on the early stages of the disease. Their levels were higher in the patients with the dementia as compared with the individuals without it. There were no differences in cortical, subcortical and combined typesof dementia. The authors believe, that some of the proteins studied (neuron specific enolase, for example) may serve as non specific markers of cerebral degeneration.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 06:21:28