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Titolo:
Tumor progression and survival in patients with T1G3 bladder tumors: Multicentric retrospective study comparing 94 patients treated during 17 years
Autore:
Patard, JJ; Moudouni, S; Saint, F; Rioux-Leclercq, N; Manunta, A; Guy, L; Ballanger, P; Lanson, Y; Hajri, M; Irani, J; Guille, F; Beurton, D; Lobel, B;
Indirizzi:
Ctr Hosp Univ Rennes, Dept Urol, Rennes, France Ctr Hosp Univ Rennes Rennes France iv Rennes, Dept Urol, Rennes, France CHU Henri Mondor, Dept Urol, F-94010 Creteil, France CHU Henri Mondor Creteil France F-94010 pt Urol, F-94010 Creteil, France CHU Rennes, Dept Pathol, Rennes, France CHU Rennes Rennes FranceCHU Rennes, Dept Pathol, Rennes, France CHU Clermont Ferrand, Dept Urol, Clermont Ferrand, France CHU Clermont Ferrand Clermont Ferrand France , Clermont Ferrand, France CHU Bordeaux, Dept Urol, Bordeaux, France CHU Bordeaux Bordeaux FranceCHU Bordeaux, Dept Urol, Bordeaux, France CHU Tours, Dept Urol, Tours, France CHU Tours Tours FranceCHU Tours, Dept Urol, Tours, France Hop Charles Nicolle, Dept Urol, Tunis, Tunisia Hop Charles Nicolle TunisTunisia es Nicolle, Dept Urol, Tunis, Tunisia CHU Poitiers, Dept Urol, Poitiers, France CHU Poitiers Poitiers FranceCHU Poitiers, Dept Urol, Poitiers, France Hop Ambroise Pare, Dept Urol, Boulogne, France Hop Ambroise Pare Boulogne France ise Pare, Dept Urol, Boulogne, France
Titolo Testata:
UROLOGY
fascicolo: 4, volume: 58, anno: 2001,
pagine: 551 - 556
SICI:
0090-4295(200110)58:4<551:TPASIP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSITIONAL-CELL-CARCINOMA; BACILLUS CALMETTE-GUERIN; 2ND TRANSURETHRAL RESECTION; RADICAL CYSTECTOMY; CANCER; STAGE-T1; THERAPY; RECURRENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Patard, JJ CHU Pontchaillou, Serv Urol, Rue Henri Guilloux, F-35033 Rennes, France CHU Pontchaillou Rue Henri Guilloux Rennes France F-35033 ance
Citazione:
J.J. Patard et al., "Tumor progression and survival in patients with T1G3 bladder tumors: Multicentric retrospective study comparing 94 patients treated during 17 years", UROLOGY, 58(4), 2001, pp. 551-556

Abstract

Objectives. To compare tumor recurrence, progression, and patient survivalin T1G3 bladder tumors treated with transurethral resection (TUR) alone, early cystectomy, or TUR with an adjuvant 6-week course of bacille Calmette-Guerin (BCG) and followed up for a minimum of 5 years. Methods. Between 1979 and 1996, 94 patients with T1G3 bladder tumors (lamina propria invasion) were treated at nine different centers. The time to tumor recurrence, tumor stage and grade progression, number of delayed cystectomies, and patient survival were analyzed retrospectively in relation to the initial treatment. Results. The mean follow-up was 62 months. Thirty patients were treated byTUR alone (32%), 50 patients by TUR plus BCG (53%), and 14 patients by primary cystectomy (15%). The recurrence, progression, and cystectomy rates were significantly different between patients treated by TUR alone and TUR plus BCG (Fisher's exact test, P = 0.0005, P = 0.02, and P = 0.005, respectively). The disease-free survival was also significantly different when comparing TUR plus BCG with TUR alone or primary cystectomy (Kaplan-Meier analysis, log-rank test, P = 0.02). Conclusions. Endoscopic resection plus BCG treatment of pT1G3 tumors allows an 80% rate of disease-free 5-year survival with bladder preservation. This conservative option has been widely accepted as first-line treatment, offering good cancer control with excellent quality of life. Very accurate surgical and pathologic evaluations before treatment and lifelong follow-up are obviously required. (C) 2001, Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 14:18:46