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Titolo:
Ultrasonographic assessment of coronary flow reserve and abdominal fat in obesity
Autore:
Kondo, I; Mizushige, K; Hirao, K; Nozaki, S; Tsuji, T; Masugata, H; Kohno, M; Matsuo, H;
Indirizzi:
Kagawa Med Univ, Dept Internal Med 2, Kita Ku, Kagawa 7610793, Japan Kagawa Med Univ Kagawa Japan 7610793 d 2, Kita Ku, Kagawa 7610793, Japan
Titolo Testata:
ULTRASOUND IN MEDICINE AND BIOLOGY
fascicolo: 9, volume: 27, anno: 2001,
pagine: 1199 - 1205
SICI:
0301-5629(200109)27:9<1199:UAOCFR>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOPPLER GUIDE-WIRE; DIABETIC RAT MODEL; INSULIN-RESISTANCE; GLUCOSE-INTOLERANCE; PREDIABETIC STAGE; BLOOD-FLOW; ECHOCARDIOGRAPHY; MELLITUS; ACCUMULATION; VASODILATION;
Keywords:
obesity; insulin resistance; coronary flow velocity reserve; Doppler echocardiography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Mizushige, K Kagawa Med Univ, Dept Internal Med 2, Kita Ku, 1750-1 Miki, Kagawa 7610793, Japan Kagawa Med Univ 1750-1 Miki Kagawa Japan 7610793 0793, Japan
Citazione:
I. Kondo et al., "Ultrasonographic assessment of coronary flow reserve and abdominal fat in obesity", ULTRASOUN M, 27(9), 2001, pp. 1199-1205

Abstract

Recent technological advances in transthoracic Doppler echocardiography (TTDE) have provided noninvasive measurement of coronary flow velocity reserve (CFVR). We aimed to quantitate a correlation between endothelial dysfunction and fat distribution. In 36 patients with obesity, 16 with noninsulin-dependent diabetes mellitus (DM) and 12 healthy volunteers, coronary flow velocity was measured at the distal site of the left anterior descending branch. CFVR was defined as the ratio of hyperemic (IV infusion of 0.15 mg/kg/min adenosine) to basal peak diastolic flow velocity. Abdominal wall fat index (AWFI) was estimated by ultrasonography. Insulin resistance was quantified by the euglycemic hyperinsulinemic clump method. AWFI was significantly related to CFVR (r = -0.46, p=0.011) and insulin resistance (r = -0.71, p<0.0001). CFVR could be noninvasively evaluated using TTDE. Coronary endothelial dysfunction indicated as CFVR, body fat distribution and insulin resistance was quantitatively correlated in obesity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 16:36:14