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Titolo:
Improved 3-D-echocardiographic endocardial border delineation using the contrast agent FS069 (Optison (R)) transesophageal studies in a porcine model
Autore:
Handke, M; Schafer, DM; Heinrichs, G; Magosaki, E; Lutter, G; Dern, P; Bode, C; Geibel, A;
Indirizzi:
Univ Freiburg, Dept Cardiol & Angiol, Freiburg, Germany Univ Freiburg Freiburg Germany Dept Cardiol & Angiol, Freiburg, Germany Univ Freiburg, Dept Cardiovasc Surg, Freiburg, Germany Univ Freiburg Freiburg Germany Dept Cardiovasc Surg, Freiburg, Germany
Titolo Testata:
ULTRASOUND IN MEDICINE AND BIOLOGY
fascicolo: 9, volume: 27, anno: 2001,
pagine: 1185 - 1190
SICI:
0301-5629(200109)27:9<1185:I3EBDU>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RIGHT-VENTRICULAR VOLUME; 3-DIMENSIONAL ECHOCARDIOGRAPHY; MYOCARDIAL CONTRAST; 2-DIMENSIONAL ECHOCARDIOGRAPHY; INFARCT MASS; WALL-MOTION; REAL-TIME; IN-VITRO; ULTRASOUND; QUANTIFICATION;
Keywords:
3-D echocardiography; contrast agent; endocardial border delineation; spatial resolution; Optison; FS069;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Handke, M Univ Klin Freiburg, Abt Kardiol & Angiol, Hugstetter Str 55, D-79106 Freiburg, Germany Univ Klin Freiburg Hugstetter Str 55 Freiburg Germany D-79106 y
Citazione:
M. Handke et al., "Improved 3-D-echocardiographic endocardial border delineation using the contrast agent FS069 (Optison (R)) transesophageal studies in a porcine model", ULTRASOUN M, 27(9), 2001, pp. 1185-1190

Abstract

3-D echocardiography has the potential for quantitative assessment of regional wall motion. However, the 3-D procedures used to date do not provide the same spatial and temporal resolution as 2-D echocardiography, which results in problems with border delineation of the endocardium. There are, as yet, few studies testing if the use of contrast agent can improve endocardial definition in the 3-D data set. FS069 (Optison(R)) was used for the firsttime for this purpose in the present study. A total of 12 mechanically-ventilated pigs were examined by transesophageal 3-D echocardiography, 1. using fundamental imaging and 2. following left-atrial injection of FS069 (Optison(R)). The left ventricle was analyzed using an 18-segment model. Score with the value 0 (not visible), 1 (moderately visible) and 2 (well defined) were used to rate endocardial definition. All segments were assessed both end-diastolic and end-systolic. Various LV regions were examined by groupingsegments (anterior/lateral/inferior and basal/mid-ventricular/apical). Using the contrast agent, the proportion of nonvisible segments fell diastolicfrom 40 (18.5%) to 15 (6.9%), and systolic from 26 (12.0%) to 11 (5.1%). The proportion of well defined segments increased diastolic from 62 (28.7%) to 108 (50%) and systolic from 73 (33.8%) to 123 (56.9%). The mean visibility score increased diastolic from 1.10 +/-0.68 to 1.43 +/-0.62 (p<0.001), systolic from 1.22<plus/minus>0.64 to 1.52 +/-0.59 (p<0.001). The benefit was greatest in regions where the visibility score was lowest without contrast: in the area of the lateral wall and systolic near the apex. In conclusion, the use of FS069 (Optison(R)) results in significantly better endocardial delineation in the 3-D data set. This could be important in future for the 3-D echocardiographic assessment of regional wall motion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 18:49:47