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Titolo:
Targeting kinin receptors for the treatment of tissue ischaemia
Autore:
Emanueli, C; Madeddu, P;
Indirizzi:
Natl Inst Biostruct & Biosyst, Natl Lab, Cardiovasc Med & Gene Therapy Sect, Osilo, Italy Natl Inst Biostruct & Biosyst Osilo Italy ne Therapy Sect, Osilo, Italy Med Univ Sassari, Dept Internal Med, Sassari, Italy Med Univ Sassari Sassari Italy ssari, Dept Internal Med, Sassari, Italy
Titolo Testata:
TRENDS IN PHARMACOLOGICAL SCIENCES
fascicolo: 9, volume: 22, anno: 2001,
pagine: 478 - 484
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; COLLATERAL VESSEL DEVELOPMENT; ANGIOGENESIS IN-VIVO; GENE DELIVERY; BLOOD-FLOW; MYOCARDIAL-INFARCTION; NEOINTIMA FORMATION; SKELETAL-MUSCLE; B-1 RECEPTORS; KNOCKOUT MICE;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Emanueli, C Natl Inst Biostruct & Biosyst, Natl Lab, Cardiovasc Med & GeneTherapy Sect, Osilo, Italy Natl Inst Biostruct & Biosyst Osilo Italy ect, Osilo, Italy
Citazione:
C. Emanueli e P. Madeddu, "Targeting kinin receptors for the treatment of tissue ischaemia", TRENDS PHAR, 22(9), 2001, pp. 478-484

Abstract

Kinins, the biological end-products of the kallikrein-kininogen system, influence many aspects of the cellular function. Interest in this peptidergicsystem has been renewed recently by the discovery that kinins exert cardiovascular protective effects and promote post-ischaemic recovery by stimulating vascular growth. Pharmacological and genetic studies indicate that induction of kallikrein and kinin receptors by ischaemia is functionally relevant in the natural host response that permits perfusion recovery and tissue healing. Furthermore, potentiation of the generation of kinins by continuous supply of tissue kallikrein promotes reparative angiogenesis through stimulation of the release of nitric oxide and prostaglandins. Strategies that activate kinin receptors might be applicable to the treatment of occlusive vascular disease, whereas kinin receptor antagonists could represent therapeutic reagents against pathological angiogenesis in cancer and chronic inflammatory conditions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 06:21:51